activated macrophage


Also found in: Dictionary, Thesaurus, Medical.

activated macrophage

[′ak·tə‚vād·əd ′mak·rə‚fāj]
(immunology)
A macrophage whose ability to destroy microbes or other cells has been enhanced because of stimulation by a lymphokine.
Mentioned in ?
References in periodicals archive ?
These cells usually are referred to as alternatively activated macrophages (M2) and help promote the resolution of inflammation as well as tissue repair (Sica and Mantovani 2012) (see figure 1).
New investigations have emerged involving interspinal transplants, chemical agents, activated macrophages, oligodendrocytes, and a group known as olfactory ensheathing cells (OECs).
Furthermore, sustained overproduction of nitric oxide (NO) generated from inducible nitric oxide synthase (iNOS) expressed in activated macrophages and endothelium, can lead to a modulation of leukocyte infiltration, a cyclo-oxygenase-2 (COX-2)-dependent production of inflammatory prostaglandins (PGs), and an interaction of NO with leukocyte-derived [O.
Proneuron Biotechnologies, a privately held company, today announced the initiation of a second Phase 1 clinical trial of autologous activated macrophage therapy for patients with complete spinal cord injury.
Proneuron Biotechnologies, a privately-held company, today announced the enrollment of the first patient in a Phase 1 study to assess the safety of autologous activated macrophage therapy in the treatment of patients with complete spinal cord injury.
Activated macrophages play an important role in the progression of various inflammatory diseases.
Classically activated macrophages (CAMs) are induced by recognition of microbial patterns (Padgett et al.
tuberculosis versus avirulent strains involve both TNF production and TNF inactivation by released soluble TNFR2 from activated macrophages [23, 49].
Additionally, oxidative burst is also required in the clearance of apoptotic cells by alternatively activated macrophages during wound healing process [53].
sup][2] Activated macrophages secrete several pro-inflammatory cytokines and growth factors, which induce renal tubular epithelial cell apoptosis, activate fibroblast, stimulate extracellular matrix (ECM) production, and finally result in renal fibrosis.
19 Activated macrophages in the wound secrete the pro-angiogenic cytokines.

Full browser ?