(a) The bivalent include bivalirudin and lepirudin; bind both to the active site
and Exosite 1 (E1) of thrombin.
* When a dNTP pauses in the active site
, the polymerase catalyzes formation of a chemical bond between the 3'-OH of the primer (nascent strand) and the innermost (alpha) phosphate of the incoming dNTP.
Unlike the average hydrogen production rate over some time, this local hydrogen production rate contains wealth of information about the active site
and can help for understanding of the catalyst surface characteristics and its photocatalytic performance directly.
The Cys-592 (marked as CME 592) is a key residue located at the mobile flap covering the active site
, one per each of the six sites in the hexameric molecule .
When MAO is used as cocatalyst, PBs with broad MWDs are produced because of the heterogeneous nature of the active sites
Explain that heat, symbolized by the scissors, caused weak hydrogen bonds, symbolized by the rubber band, to break, thus denaturing the enzyme and eliminating its active site
In all of the liganded forms, the flaps are pulled in toward the bottom of the active site
("closed" form), whereas the structures for the unbound enzyme all adopt a "semi-open" conformation with the flaps shifted away from the triads, but still substantially closed over the active site
and in contact with each other, blocking entry to the active site
First, the structure of the integrase protein complex isn't fully understood, and the "active site
" where a drug might attach is shallow.
The active site
loop of hTS has a unique conformation resulting from a rotation by 180 [degrees] relative to its orientation in bacterial TSs.
It relates to a chemical compound, called a transition state analogue, with a structure that resembles the transition state of a substrate molecule that can block the active site
of a bacterial enzyme.
Fracking, also known as hydraulic fracturing, has been the focus of considerable controversy in recent weeks, after a number of earthquakes around the UK's only active site
, near Blackpool.