active site

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Related to active sites: Lock and Key Model, induced fit model

active site:

see enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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active site

[′ak·tiv ′sīt]
The effective site at which a given heterogeneous catalytic reaction can take place. Also known as active center.
(cell and molecular biology)
The region of an enzyme molecule at which binding with the substrate occurs. Also known as binding site; catalytic site.
References in periodicals archive ?
6 bioinformatics tools for examining DNA sequences, studying protein structure, and identifying active sites.
Another small family of lipases with an emerging role in lipid mobilization in insects, the adipose- triglyceride-lipase (ATGL) family (PF01734), also have an N-terminal domain with a predicted alpha/beta hydrolase fold and an active site serine residue (Zimmermann et al.
However, the MWD cannot be controlled effectively, which is generally attributed to the heterogeneity of the catalyst system and to the existence of multiple active sites [1-10].
Explain that heat, symbolized by the scissors, caused weak hydrogen bonds, symbolized by the rubber band, to break, thus denaturing the enzyme and eliminating its active site.
HOT SPOTS The geologically active sites where these scientists work represent two extremes of the global tectonic system.
For specialists in the field of the synthesis, mathematical modeling, and physical chemistry of high-molecular compounds, three Russian scientists, perhaps from the Russian Academy of Sciences, present data on active sites and their kinetic and stereo-specific heterogeneity or multiplicity in ionic, ionic-coordinate, and complex radical polymerization processes of olefin and diene monomers.
However, many researchers believe that ZSM-5 zeolite provides a unique environment for catalytic active sites for this reaction, and spend extensive effort to understand these catalysts which suffer from deactivation problems.
A glycerol molecule and sulfate ion in each of the active sites was found mimicking a transition state analog.
Because Hernandez appreciates such sites as works in progress, his camera reveals them not as sealed exhibits of urban collapse, but as active sites of deconstruction: There is a sense of abandon in these abandoned places, a suggestion of illicit transformations, of an infra-architecture at once degenerating and reconfiguring itself before our eyes (a tender irony inflects his image of an architectural office that seems, literally, to have gone to seed).
Of the five final active sites, only one is in Rosamond.
The newest active sites added to the Phase II/III clinical trial include the University of Colorado, Denver; Oregon Health Science Center, Portland; and University of California, San Francisco.
In addition, because of their unique structure they can also address therapeutic opportunities that are beyond the reach of conventional antibodies or their fragments, for example targeting epitopes such as receptor clefts, enzyme active sites and viral canyon sites.

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