The following conclusions were derived from the study: A general phenomenon of acute phase response
with raised serum alpha-1 AT and raised NBT positivity is seen in CRF patients.
In conclusion, in the light of our results, we may conclude that cellular immunity is increased, but acute phase response
remains normal in patient with FEP The severity of psychopathology is not associated with acute phase and cellular response in FEP patients.
Acute phase response
to single and repeated bouts concurrent resistance and endurance exercise.
Reduced serum iron is the favourable result of the acute phase response
to deter bacterial growth.
It could be concluded that the higher serum levels of IgG, IgM, C1-INH and C3 activator in SCA patients with osteomyelitis coupled with the strong positive correlation found between the traditional markers of infection (elevated ESR and leukocytosis) and IgM, C1-INH and C3 activator reinforces their being classed as acute phase response
Professor Obled from France provided an overview of the acute phase response
including the mediators produced and their consequent metabolic effects; she highlighted the importance of this response in host survival.
A review on the acute phase response
in major depression.
She explains the role of CRP in the acute phase response
, its connection to atherogenesis, the effects of statin therapy in lowering levels of CRP and reducing cardiac events, using CRP as a measure of outcome in patients with severe unstable angina, and the possibility of a connection between elevated levels of CRP and cardiac risk in women on postmenopausal hormone therapy.
Discussion: Data indicate clearance is inversely related to the acute phase response
(as the inflammatory process resolves individual clearance improves).
Although the acute phase response
is non-specific and on its own has no diagnostic significance, the sensitivity, speed and dynamic range of the CRP response to most forms of infection, inflammation and tissue injury combine to make it an exceptionally useful objective index of disease activity and response to therapy .