acute-phase protein


Also found in: Medical, Wikipedia.

acute-phase protein

[ə¦kyüt ¦fāz ′prō‚tēn]
(immunology)
Any of a group of proteins that are produced by the liver and appear in the blood in increased amounts shortly after the onset of infection or tissue damage; they include C-reactive protein, fibrinogen, proteolytic enzyme inhibitors, and transferrin.
References in periodicals archive ?
Pentraxin-3 (PTX-3) is a novel acute-phase protein detected as an inflammatory response of the body.1-3 The pentraxin family is divided into two groups as short, and long; PTX-3 is a prototype of the long pentraxin family (molecular weight, 440 kDa), which is produced by the vascular epithelium, smooth muscle, lung epithelial cells, monocytes, macrophages, fatty tissue, and mostly by the liver in various organs as an inflammatory response of the body.4-7
Because the aim of this study was to identify the association between liver-secreted acute-phase protein SAA baseline concentrations and its gene copy numbers, the hepatic and inflammatory indices of 250 Chinese participants were carefully examined.
Ganz, "Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein," Blood, vol.
Sheikh et al., "Ferroportin-1 is a nuclearnegative acute-phase protein in rat liver: A comparison with other iron-transport proteins," Laboratory Investigation, vol.
Ferroportin-1; a negative acute-phase protein (Naz et al., 2012), is regulated by hepcidin under inflammatory conditions (Fleming et al., 2005; Ganz2005; Nemeth et al., 2004; Sheikh et al., 2007).
Among them is Serum Amyloid A (SAA), an acute-phase protein which is principally synthesized by the liver in response to acute inflammatory stimuli.
[9] CRP is an acute-phase protein synthesized predominantly by the hepatocytes in response to tissue damage or inflammation.
In the current study, detection of anti-Aspergillus antibodies, Aspergillus antigen, and Aspergillus toxin (fumigaclavine A), protein electrophoresis and measurement of acute-phase protein concentrations were performed on serum of 18 adult and plasma of 21 juvenile gyr-saker hybrid falcons (Falco rusticolus X Falco cherrug).
The rapid, disposable, in-office assay provides the interpretation of both Myxovirus Resistance Protein A (MxA), an interferon derivative that becomes increased in the presence of acute viral infection, as well as C-reactive Protein (CRP), an acute-phase protein that is higher when bacterial infection is present.
In addition, it is an acute-phase protein and is positively associated with necrosis and inflammation [36].
TRFE (transferrin) is a negative acute-phase protein and is the most important glycoprotein for transport of iron in human body [51].
(4) These cytokines act to stimulate hepatic acute-phase protein synthesis, endothelial cell adhesion, and angiogenesis, along with a myriad of other responses.