acute-phase reaction


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acute-phase reaction

[ə¦kyüt ¦fāz rē′ak·shən]
(immunology)
During inflammation, change in the rates of synthesis of certain serum proteins that are important in nonspecific defense reactions.
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HDL and LDL cholesterol are depressed during sepsis as part of a cytokine-mediated acute-phase reaction (2).
Some proteins (alpha 1 -antitrypsin, alpha 1-acid glycoprotein, haptoglobin, ceruloplasmin, C4, C3 and C-reactive protein) will increase in response to an acute-phase reaction and are known as positive acute- phase proteins.
Another acute-phase reaction, elevated levels of C-reactive protein, may occur.
Under stable conditions, CRP concentrations reflect inflammation in the vasculature but are boosted in the acute phase of NSTEACS due to the acute-phase reaction resulting from myocardial necrosis.
The hyperferritinemia in AOSD may not simply be secondary to the disease process as part of an acute-phase reaction, but could be causative in the condition, maybe involving iron-mediated oxidative damage or even a mutated form of ferritin.