Indications of an acute-phase reaction
at the initial stages of infection were not detected.
The hyperferritinemia in AOSD may not simply be secondary to the disease process as part of an acute-phase reaction
, but could be causative in the condition, maybe involving iron-mediated oxidative damage or even a mutated form of ferritin.
Some proteins (alpha 1 -antitrypsin, alpha 1-acid glycoprotein, haptoglobin, ceruloplasmin, C4, C3 and C-reactive protein) will increase in response to an acute-phase reaction
and are known as positive acute- phase proteins.
Lipton, patients treated with denosumab had an 8% incidence of a flu-like, acute-phase reaction
during the first 3 days after the start of treatment, compared with a 33% rate in patients randomized to treatment with an intravenous bisphosphonate.