It is postulated that position and numbers of hydroxyl group in anthrarobin are responsible for antioxidant potential and the activity decreases with the substitution of acyl groups
at various positions in synthesized derivatives.
In the same time, it was noticed the importance of the presence of a hydroxyl group at C-8, as in penicillosides F and G, which are still active inspite of their less lipophilicity than pencillosides D and E with only one acyl group
(benzoyl) which may be compensated with the prsence of a hydroxyl group at C-8.
Disubstituted compounds were obtained from the reactions of 4 with methyl iodide, benzyl chloride, acetyl chloride, benzoyl chloride, 4-methoxybenzoyl chloride, 2-chlorobenzoyl chloride and propanoyl chloride in acetone in the presence of K2CO3 via replacement of all the oxime protons with alkyl and acyl groups
The "family" of acylcarnitines analyzed by MS/MS include fatty acyl groups
for saturated and unsaturated species ranging from the 2-carbon acetylcarnitine (C2) through the 20-carbon aliphatic groups (27).
Since carnitine is a vehicle by which the acyl groups
can leave the mitochondria and there is an equilibrium between acylcarnitines and their respective CoA thioesters, the analysis of carnitine and acylcarnitines in blood is approximately equivalent to the analysis of acyl-CoAs in the mitochondria.
Fatty acid ester are hydrolyzed by esterases and lipases, but esterases hydrolyze the ester bonds of the water's soluble fatty acid ester with short-chain acyl groups
([less than or equal to] [C.
1996), this is probably due to the presence of the acyl groups
present in the HA gellan, preventing the association between the biopolymer chains (Chandrasekaran and Thailambal, 1990).
Carnitine prevents accumulation of acetyl and acyl groups
which inhibit the [beta]-oxidation.