All viruses have M2-31N, which might be involved in resistance to
adamantane (9).
Notably, the resulting Adm-p-MMA-b-gly/NC contained
adamantane core, as a new functionality.
Carbon chemical shifts were referred to the carbon methylene signal of solid
adamantane at 28.
Distribution and implication of
adamantane in crude oils in Lunnan area, Tarim basin in China.
The sample MAS was 10 kHz, and chemical shifts were referenced to
Adamantane (left peak) at 38.
Adamantane is the simplest, consisting of a single cage of the lattice.
Larisa Gubareva of the Centers for Disease Control and Prevention in Atlanta, and their colleagues, tested seasonal H1N1 viruses collected between 2008 and 2010 for resistance to two types of antivirals: oseltamivir and
adamantane drugs.
Optimization of the Hartmann-Hahn conditions was achieved using an
adamantane sample.
They found that about one-third of those samples carried mutations enabling the virus strains to resist the effects of
adamantane drugs.
Annual influenza vaccination is recommended to prevent flu, but in addition, two antiviral
adamantane drugs (amantadine and rimantadine) and two neuraminidase inhibitors (oseltamivir and zanamivir) are currently approved to prevent and/or treat influenza.
Recently, pyrosequencing was also used for determination of HIV resistance mutations (23) or influenza virus resistance to
adamantane (24).
As a top maker of hydrogen peroxide, Mitsubishi has engaged in the manufacture of
adamantane derivatives.