Molecular modeling of the major adduct
of (+)-anti-B[a]PDE ([N.
In addition, SNPs present in metabolism and DNA repair genes were selected a priori by the consortium as candidate genes based on the available knowledge on functionalities with respect to bioactivation (CYP1A1, CYP2E1, CYP2D6, EPHX1, and EPHX2) and detoxification (GSTM1) of DNA adduct
-forming metabolites, base excision repair of oxidative adducts
(OGG1), nucleotide excision repair of bulky adducts
(XRCC1, ERCC2/XPD, XPA, and XRCC3), repair of alkylated adducts
(MGMT, ALKB, and MPG) and of thymine adducts
(TDG), and with respect to folate metabolism, which is known to interfere with micronucleus formation (MTHFR, MTR, and MTRR).
This paper reports the details of a synthetic strategy for preparing the urethane linkage-based prepolymers from several precursor compounds such as isocyanate adducts
, sterols, and hydroxyesters, etc.
Analysis of the erythrocyte sample from a healthy volunteer showed only the intact Hb and no adduct
with oxaliplatin (Fig.
New hindered amine adducts
have been developed which yield aliphatic polyurea systems that have the potential to replace multiple coat systems with a single direct-to-metal exterior coating.
The major reactive molecules participating in adduct
formation appear to be those that are chemically known as aldehydes, specifically acetaldehyde, MDA, and HNE (Niemela 2001; Tuma and Sorrell 1995).
Phenolic-epoxy matrix resin was used directly for composite preparation in second mode wherein the intermediate PR-EP adduct
formation as visualized during prepreg preparation was avoided.
In contrast to genistein, the saponins inhibited adduct
formation whether or not they had sugar molecules attached to them.
We have preliminary evidence that the adduct
interferes with one of the enzymes that is supposed to be chopping up the protein.
Our research also found that compounds similar to MLN4924 form analogous adducts
that inhibit activating enzymes related to NAE.
In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study, higher intake of fibers was negatively associated with bulky DNA adduct
levels in white blood cells from 1,085 adults (Peluso et al.
In other cases, especially when the parent compound is quickly metabolized or otherwise difficult to measure, a metabolite or a DNA or protein adduct
may be preferable.