"Exposure to high glucose levels leads to both DNA
adducts and the suppression of their repair, which in combination could cause genome instability and cancer," Termini explained.A
Indeed, they found a DNA
adduct, called N2-(1-carboxyethyl)-2'-deoxyguanosine, or CEdG, that occurred more frequently in the diabetic models than in normal cells or mice.
The mechanism of action of cisplatin is mediated by the interaction of cisplatin with DNA in order to for DNA
adducts. The principle of action involves exerting its cytotoxicity upon cancer cells through the formation of DNA
adducts that include mono-, inter, and intrastrand cisplatin DNA crosslinks that arrest the cell cycle at S, G1 or G2-M thus induces apoptosis (3).
Amine functional
adducts (Figure 2) were synthesized with excess amine.
Amendola, Insight on Mendahle Resin Made by Combining Diels-Alder Epoxy
Adducts with DGEBA.
[24] were the first to conduct a meta-analysis to investigate the influence of the GSTM1 genotype on the formation of DNA
adducts. Their results showed that the DNA
adduct levels in null GSTM1 carriers were significantly higher than those in active GSTM1 carriers among workers who were occupationally exposed to PAHs.
This case highlights the clinical value of checking for and removing DNA
adducts and calls attention to the need for further research into the possible roles of FPRs in neurodegenerative diseases.
The geometry of the azole-amino acids
adducts was optimized using four different functionals, including hybrid, GGA, and meta-GGA functionals, that is, B3LYP, CAM-B3LYP, PBE0, and M06L.
The new patent covers the methods for measuring these nucleosome-protein complexes, known as "
adducts."
In cytoplasm, BPDE (C) forms tetrols (T), protein
adduct (A) and GSH conjugation
(27) Acetaldehyde binds to microsomal enzymes, proteins, and microtubules to form
adducts. These
adducts react with brain dopamine to form salsolinol, a chief chemical involved in the alcohol dependence mechanism.
Baylis-Hillman
adducts have been widely used in the synthesis of several useful acyclic compounds and cyclic compounds including heterocyclic ones.