The CDC has measured the hemoglobin adducts
of acrylamide and its metabolite glycidamide (CDC 2009) and plans to measure urinary mercapturic acid metabolites of acrylamide and glycidamide in NHANES participants (Alwis et al.
The metabolites can bind with proteins to form stable adducts
called MDA--acetaldehyde--protein adduct
The level of adduct
formation found in this study was quantitatively similar to that of the major adduct
produced in vivo, although other adducts
were not detected.
The strategy for obtaining functional polymeric agents is based on a multistep process involving the preparation of precursor compounds such as isocyanate adducts
, esterols and hydroxyesters, followed by reacting each of them with others to get a product with the free isocyanate groups.
The clinical and lab findings of the patients who had adducts
equal to 1 nmol/mL or greater were consistent with findings--including very high aminotransferases, low bilirubin, and favorable outcome--for known APAP overdose patients.
The shift toward higher percentages of sodium adducts
with some methanol types (Table 1) could contribute to the lower ion response for the ammonium precursor ion that is used in the immunosuppressant assays.
amino acids) and other molecules in the cell to form both stable and unstable adducts
(see Table 2).
Beverly Hills, CA) for the isolation of mononuclear leucocytes and the determination of 8-OH guanine DNA adducts
The Consultation reviewed the methods of analysis available to test for acrylamide in foodstuffs and food ingredients, and for acrylamide and its metabolites as haemoglobin adducts
The RecFOR pathway of homologous recombination (HR) repairs daughter strand gaps (DSGs) formed when DNA adducts
are not repaired by NER before replication.
In particular, to establish spectroscopic signatures for heme systems, we have prepared five-coordinate adducts
of the ferrous myoglobin H94G cavity mutant with neutral thiol and thioether sulfur donors as well as six-coordinate derivatives such as with CO, NO, 02 and bis-ligated complexes.
SynTECH[TM] is a no-clean solder paste made with synthetic poly adducts
that yields reliable solder joints in surface-mount PCB assemblies.