McCluggage, "HPV-negative Gastric Type
Adenocarcinoma in Situ of the Cervix," The American Journal of Surgical Pathology, vol.
Adenocarcinoma in situ of the cervix: an underdiagnosed lesion.
Symposium part I:
adenocarcinoma in situ, glandular dysplasia, and early invasive adenocarcinoma of the uterine cervix.
A and B, Small fragments ofendocervical
adenocarcinoma in situ (AIS) in an endocervical curettage with nuclear atypia, hyperchromasia, crowding, and frequent apical mitoses (arrows).
The frozen section diagnosis of
adenocarcinoma in situ and minimally invasive adenocarcinoma from invasive carcinoma has been a debated topic.
Cervical glandular neoplasia, including
adenocarcinoma in situ (AIS) and invasive adenocarcinoma, is less common than squamous neoplasia.
Adenocarcinoma in situ is defined as a small ([less than or equal to] 3 cm) solitary adenocarcinoma with pure lepidic growth and no stromal, vascular, or pleural invasion.
(2) Furthermore, PAX8 was expressed in 97% to 100% of
adenocarcinoma in situ (AIS) and in 0% to 87% of endocervical adenocarcinoma (ECA) specimens (summarized in Table 1).
As we have over the decades come to better understand lung neoplasia and preneoplasia, bronchioloalveolar carcinoma (far from being understood as a single, specific lesion as it was originally considered) has leant its appellation to 5 clinically and pathologically distinct entities, namely, 3 nonmucinous lesions (
adenocarcinoma in situ, minimally invasive adenocarcinoma, and adenocarcinoma with a prominent lepidic pattern) and 2 mucinous lesions (mucinous
adenocarcinoma in situ and mucinous adenocarcinoma).
Combining the most clinically significant cytologic abnormalities of high-grade squamous intraepithelial lesion,
adenocarcinoma in situ, and carcinoma, the highest reporting rates were with SurePath and ThinPrep (0.9%), followed by Lituo (0.8%), Liqui-Prep (0.5%), and CPT (0.3%).
Adenocarcinoma in situ (AIS) is a well-known precursor of invasive cervical adenocarcinoma.
(1) Lung
adenocarcinoma in situ (AIS, previously classified as bronchioloalveolar carcinoma) and invasive adenocarcinoma with mucinous histology have been classically described in the setting of congenital pulmonary airway malformation, primarily in type 1 malformations.