Abnormal expression of sex steroid receptors and cell cycle-related molecules in
adenocarcinoma in situ of the uterine cervix.
The histologic diagnosis of
adenocarcinoma in situ must consider multiple anatomical and architectural patterns and cytologic features.
In both trials, polymerase chain reaction was used to identify the HPV subtype associated with any CIN,
adenocarcinoma in situ, or anogenital lesion that was biopsy-proven, and this information was correlated with the patient's HPV status before and after vaccination.
Diagnosis of lung
adenocarcinoma in situ and minimally invasive adenocarcinoma from intraoperative frozen sections: an analysis of 136 cases [published online ahead of print May 12, 2016].
Adenocarcinoma in situ is difficult to specifically recognize on Pap slides and the false-negative interpretation rate is significantly higher for AIS than that for other significant lesions including HSIL, squamous cell carcinoma, and adenocarcinoma.
Summary of Results of PAX8 Expression by Immunohistochemistry in Endocervical Adenocarcinoma (ECA) and
Adenocarcinoma In Situ (AIS) Source, y Cases, PAX8 Positive, No.
Adenocarcinoma in situ and minimally invasive adenocarcinomas are of special interest because of their 100% and near 100% 5-year survival, respectively, if completely resected.
Adenocarcinoma in situ is typically located at the transformation zone, although it may be present high up in the endocervical canal (between 20 and 30 mm, measured from the maximal convexity of the portio vaginalis).
Repeat CT scan after 3 months revealed growth of the lesion, and a transthoracic needle biopsy was performed, from which a diagnosis of nonmucinous
adenocarcinoma in situ (AIS, formerly bronchioloalveolar carcinoma (2)) was made.
This is a case that performed poorly: of the 88 participants in this case, 28% called it abnormal (18% adenocarcinoma, 5%
adenocarcinoma in situ, and 5% highgrade intraepithelial lesion/carcinoma).
Distribution of preceding Papanicolaou (Pap) test diagnoses divided into ''low-grade'' (atypical squamous cells of undetermined significance [ASC-US] and low-grade squamous intraepithelial lesion [LSIL]) and ''high-grade'' (low-grade squamous intraepithelial lesion, a highgrade squamous intraepithelial lesion cannot be ruled out [LSIL-H]; atypical squamous cells, a high-grade squamous intraepithelial lesion cannot be ruled out [ASC-H]; high-grade squamous intraepithelial lesions [HSIL]; atypical glandular cells [AGC];
adenocarcinoma in situ [AIS]; squamous cell carcinoma).
1) The new concepts of
adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) are also addressed in more detail in the article on resection specimens.
