It is difficult to exclude a small component of adenocarcinomatous
component in GCT because single cells or small clusters of neoplastic cells may be present from tangential sectioning or when the tumor infiltrates through the muscularis propria in seemingly single cells that resemble signet-ring cells; alternatively, it may represent a small focus of an adenocarcinomatous
0] (Dukes' B) (Left IBD done) HPR +ve for metastatic adenocarcinomatous
5,166) The adenocarcinomatous
component is always closely associated with the squamous elements, and it lacks the characteristic features of a distinctive form of salivary gland-type adenocarcinoma.
In contrast, a tumor with both typical urothelial carcinoma and adenocarcinomatous
components is classified as urothelial carcinoma with glandular differentiation.
No squamous metaplasia, transitional cell carcinomatous or adenocarcinomatous
components were noticed.
Although they are extremely useful in difficult, undifferentiated, small tumor samples to predict a likely or probable non-small cell lung cancer subtype, this strategy is not, and cannot be, 100% accurate, and these markers are not necessary if definite morphologic evidence of squamous cell or adenocarcinomatous
differentiation is present.