adherens junction


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adherens junction

[ad′hir·enz jəŋk·shən]
(cell and molecular biology)
An integrin-mediated anchoring junction that connects the cytoskeleton (actin filaments) of a cell to the extracellular matrix or to the cytoskeleton of surrounding cells.
References in periodicals archive ?
alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture.
Glutamine ameliorated VILI by improving the cytokines and increasing the adherens junction protein E-cadherin and p120-catenin to enhance the epithelial barrier.
Differentially expressed, enriched miRNAs from HLCs compared to hepatocytes control fatty acid biosynthesis and metabolism, ECM-receptor interaction, proteoglycans in cancer, Hippo signaling pathway, adherens junction, lysine degradation, prion diseases, viral carcinogenesis, pathways in cancer, p53 signaling pathway, and cell cycle.
Johnson, "Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies," The Journal of Cell Biology, vol.
The topics include the integration of cadherin adhesion and cytoskeleton at adherens junction, making connections: guidance cues and receptors at non-neural cell-cell-junctions, tuning collective cell migration by cell-cell junction regulation, beyond cell-cell adhesion: sensational cadherins for hearing and balance, and the loss of E-cadherin-dependent cell-cell adhesion and the development and progression of cancer.
(c) Colocalization of C4.4A (green) with the adherens junction protein [beta]-catenin (red) in TES at day 28 of culture at the A/L interface.
In addition, [beta]-catenin is a critical component of the cadherin-mediated cell adherens junction. We had previously noticed that very high cellular concentrations of [beta]-catenin had a negative effect on the transcriptional activity of this protein and, therefore, the aim of this study was to find a mechanism for this negative interaction.
QCDC adjuvants altered genes involved in "Cell adhesion molecules (CAMs)" pathway and ISA adjuvants modified the pathways related with "Spliceosome", "Ubiquitin mediated proteolysis", "Adherens junction", "Lysosome", "Natural killer (NK) cell mediated cytotoxicity", "Cell cycle", "Endocytosis", and "Focal adhesion".
Vascular endothelial- (VE-) cadherin and its associated catenins are important to form adherens junction complexes for controlling endothelial cell-cell adhesion.
Our results confirm this notion and indicate that Bves is also crucial for the proper localization of adherens junction proteins along the apical border of the photoreceptor cells and RPE.
"Disruption of these adherens junction proteins or the actomyosin network that supports them either prevented the formation of the bi-layer, or caused a loss of pre-formed bi-layers.
Deconvolution combined with digital celocalization analysis to study the spatial distribution of tight and adherens junction proteins.