adipogenesis


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Related to adipogenesis: Preadipocytes

adipogenesis

[‚ad·ə·pō′jen·ə·səs]
(physiology)
The formation of fat or fatty tissue.
References in periodicals archive ?
The mostrelevant health outcomes resulting from our study were reproductive effects (decreased testosterone, skewed sex ration, decreased fertility), endocrine disruption (estrogen and androgen receptor activation, as observed biologically with BPA), and metabolism impairment (adipogenesis, increased triglycerides, obesity).
Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity.
Adipogenesis is a comprehensive term that includes commitment of mesenchymal stem cells to preadipocytes, determination and proliferation of preadipocytes, and differentiation of preadipocytes into mature adipocytes [19].
Notably, transcription factor XBP1 was also found to play crucial roles in the adipogenesis [12-15].
Several members of the fibroblast growth factor (FGF) family have been reported to regulate adipogenesis. In particular, FGF1 is produced in adipose tissue and acts through its specific receptor FGFR1 to enhance proliferation, commitment, and differentiation of preadipocytes [5-7].
The PI3K/PKB pathway is also stimulated by oxidative stress generated by ROS and enhances adipogenesis, thereby decreasing osteoclastogenesis [55].
As FSTL1 has been described as functionally implicated in a range of processes including apoptosis, inflammation, or adipogenesis, it is not surprising that some of its functions may play a significant role in the obesity development [16, 18, 19].
Adipogenesis involves hyperplastic transformation of undifferentiated preadipocytes into mature adipocytes.
Both adipogenesis and osteogenesis are strongly miR-dependent; however, in Figure 4, we indicate only the miR-30 family among a myriad of miRs discussed elsewhere [103].
Adding chemical factors to cell culture media such as ascorbate, dexamethasone (dex), and bone morphogenetic proteins (BMPs) promotes osteogenesis; serumfree medium and transforming growth factor-[[beta].sub.1] (TGF-[[beta].sub.1]) promote chondrogenesis; growth and differentiation factor 5 (GDF-5) promotes tenogenesis; platelet derived growth factor (PDGF) promotes myogenesis; and dex, insulin, and 3-isobutyl-1-methylxanthine (IBMX) promote adipogenesis (Figure 1) [3-5].
Chemerin regulates lipid metabolism and mesenchymal stem cell adipogenesis through autocrine/paracrine mechanisms (11,12).