While these results are concerning for the future success of NK adoptive immunotherapy
, higher numbers of enrolled patients are required to adequately establish the efficacy (or lack thereof) of this approach.
Conrad et al., "Generation of a multipathogen-specific T-cell product for adoptive immunotherapy
based on activation-dependent expression of CD154," Blood, vol.
A Japanese study compared the effect of adoptive immunotherapy
on 150 liver cancer patients.
Burger et al., "erbb2/her2specific natural killer cells for adoptive immunotherapy
of glioblastoma," Neuro-Oncology, vol.
Ichihara et al., "Prognostic significance of adoptive immunotherapy
with tumor-associated lymphocytes in patients with advanced gastric cancer: a randomized trial," Clinical Cancer Research, vol.
CAR-T-Cell-Based Adoptive Immunotherapy
in Hematological Malignancies.
with O-Acetyl-GD2-Specific CARs
Novel immunotherapeutic strategies being investigated to treat glioblastoma can be broadly divided into three major classes: active immunotherapy, adoptive immunotherapy
, and immunomodulatory strategies .
Kershaw, "Manipulating immune cells for adoptive immunotherapy
of cancer," Current Opinion in Immunology, vol.
Suhoski et al., "4-1BB is superior to CD28 costimulation for generating [CD8.sup.+] cytotoxic lymphocytes for adoptive immunotherapy
," The Journal of Immunology, vol.
Knol et al., "Tissue prognostic markers for adoptive immunotherapy
in melanoma," European Journal of Dermatology, vol.
Bhagwati, "Adoptive immunotherapy
using lymphokine-activated killer (LAK) cells and interleukin-2 for recurrent malignant primary brain tumors," Journal of Neuro-Oncology, vol.