The mechanism by which adrenal androgens
, including DHEA-S, are regulated is not completely understood and even though ACTH is known to stimulate DHEA-S secretion, there are clinical scenarios such as a Cushing disease and ectopic ACTH syndrome that have reported DHEA-S concentrations to be normal or even low [32-34].
The adrenal glands produce testosterone, pregnenolone, aldosterone, DHEA, progesterone, estrogen, and adrenal androgens
. Underproduction causes downstream depletion of sex hormones, which can be a strong trigger for the symptoms of both female sexual dysfunction and menopausal transition.
The reason for the relatively rare occurrence of mid-childhood ache is that, normally, adrenal secretion virtually ceases after the first year of life until around 7 years of age, when an increase occurs in adrenal androgen
(11) A potential end result of adrenal hyperfunction is the excess production of one of the three corticosteroids; Cortisol, aldosterone or adrenal androgens
Genetics, Pwpiombactcnum acnes colonization, and stress-related production of adrenal androgens
are among the factors that have been implicated, observed Dr.
Glucocorticoids and adrenal androgens
. Basic and Clinical Endocrinology 8.edition (Ed: Greenspan FS and Gardner DG.).
In this collection of ten articles international experts describe their research in adrenal development and disorders, steroidogenic enzymes, adrenal androgens
in humans an nonhuman primates, androgen synthesis and its clinical implications, a new form of congenital adrenal hyperplasia, long-term outcomes of prenatal treatment of congenital adrenal hyperplasia, syndromes involving adrenocorticotropin resistance, corticotrophin-independent Cushing Syndrome, and adrenal steroidogenesis and arterial hypertension.
The cortical hormones include glucocorticoids, aldosterone, and the adrenal androgens
. Glucocorticoids stimulate gluconeogenesis, protein metabolism, and lipolysis, and aldosterone is a major controller of sodium balance and volume status.
Not surprisingly, adrenal androgens
and bone parameters were lower among the 12 postmenopausal CAH patients, compared with the 14 still premenopausal women, he said.
Although this pioneering study can be criticized for its lack of an experimental control group, its extremely limited sample size, and its use of a physically traumatized participant population, the results strongly suggested that adrenal androgens
do influence what Waxenberg et al.
The mechanism by which the vitamin works is unknown, the textbook notes, but may be related to alteration of blood levels of various hormones, including adrenal androgens
Dexamethasone's capacity to drastically reduce adrenal androgens
is useful in reducing excessive body hair growth in women resulting from an excessive production of adrenal androgens