We measured 15 adrenal steroids
simultaneously by LCMS/MS, including aldosterone, cortisol, 18-oxocortisol, 18-hydroxycortisol, cortisone, 11-deoxycortisol, 21deoxycortisol, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, pregnenolone, androstenedione, dehydroepiandrosterone (DHEA), and DHEA-sulfate (DHEA-S).
Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Pregnanediol H H H H L 0 Androsterone H H H H L 0 Etiocholalone H H H N N 0 DHEA H H N L N 0 Pregnanetriol H H N L N 0 11-Ketoandrosterone H H N L N 0 11-ketoetiocholalone H N L L L 0 11-OH-androsterone H L L N L 0 * Case 1:54-yr-old woman hypertension, diverticulitis, palpitations, and severe Katribarelated stress.
Hollis-Eden Pharmaceuticals, a development-stage pharmaceutical company, is engaged in the development of a class of adrenal steroids
for a broad array of potential indications.
A sensitivity analysis indicated the parameter uncertainties and identified transport and metabolic processes that most influenced the concentrations of primary adrenal steroids
, aldosterone and Cortisol.
is developing a proprietary new class of small molecule compounds that are metabolites or synthetic analogs of adrenal steroid
Normal levels of circulating adrenal steroids
appear to be necessary for accurate performance on spatial tasks, which is not surprising given the role of the hippocampus in spatial learning and memory.
The results presented today support the concept that it is possible to develop a targeted therapy to block HRPC-associated tumors by interrupting their ability to use adrenal steroids
as growth factors.
Various adrenal steroids
have been measured as markers of control, but the 3 most commonly used are 17OHP, androstenedione, and testosterone.
Through years of research with these compounds -- metabolic conversions or synthetic analogs of adrenal steroid
hormones -- Hollis-Eden has made significant discoveries relating to their metabolism, mechanism of action and pharmacologic profile.
After the commencement of World War II, federal funding of adrenal steroid
research quickly waned but Merck continued their collaboration with Kendall and Hench.
To exclude a deficiency of one of the enzymes in the pathway of steroid biosynthesis as a cause, the samples were tested for adrenal steroids
Testing for adrenal steroids
is also useful for differential diagnosis of polycystic ovary syndrome and nonclassic forms of CAH, which may sometimes be indistinguishable by clinical presentation and sonography (6).