Schematic diagram showing the biosynthetic pathways for the 15 adrenal steroids
in the panel (black background) and 2 other steroids (light background) not included in the panel.
Fourth, a model that predicts the response of the major adrenal steroids
[e.g., Cortisol (CORT), aldosterone (ALDO)] to EACs can be coupled to multiorgan systems models, which include regulatory feedback of the hypothalamus-pituitary-adrenal axis and the renal-angiotensin-aldosterone system, in support of in vivo EAC screening methods.
A much smaller number of chemicals have been evaluated for effects on other endocrine systems such as androgens and adrenal steroids
. Keith (59) has compiled a comparative list of environmental endocrine disruptors based on lists obtained from scientists at the U.S.
We measured 15 adrenal steroids
simultaneously by LCMS/MS, including aldosterone, cortisol, 18-oxocortisol, 18-hydroxycortisol, cortisone, 11-deoxycortisol, 21deoxycortisol, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, pregnenolone, androstenedione, dehydroepiandrosterone (DHEA), and DHEA-sulfate (DHEA-S).
Various adrenal steroids
have been measured as markers of control, but the 3 most commonly used are 17OHP, androstenedione, and testosterone.
Development and performance evaluation of a tandem mass spectrometry assay for four adrenal steroids
. Clin Chem 2006;52:1559-67.
Because interfering substances and the degree of interference vary among commercially available immunoassays, reference intervals for adrenal steroids
are often method-specific and cannot be used interchangeably (18-23).
The majority of these articles dealt with topics in pediatric endocrinology, particularly with the urinary excretion of adrenal steroids
Reference intervals for plasma concentrations of adrenal steroids
measured by LC-MS/MS: impact of gender, age, oral contraceptives, body mass index and blood pressure status.
In some cases, patients with severe disease, or those who cannot take sulfasalazine-type drugs, are given adrenal steroids
(drugs that help control inflammation and affect the immune system).
Hollis-Eden Pharmaceuticals, a development-stage pharmaceutical company, is engaged in the development of a class of adrenal steroids
for a broad array of potential indications.
SAN ANTONIO -- Increased levels of adrenal steroids
appear to contribute to metabolic syndrome in African Americans, Dr.