adrenochrome

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Related to adrenochrome: DMT

adrenochrome

[ə′dren·ə‚krōm]

(biochemistry)

C₉H₉O₃N A brick-red oxidation product of epinephrine which can convert hemoglobin into methemoglobin.

References in periodicals archive ?

Figure 8: Prescription pattern of drugs for variceal bleeding in patients with alcoholic liver disease Propranolol 82.26% Octreotide 6.45% Ethamsylate 8.06% Adrenochrome 1.61% Tranexamic acid 1.61% Note: Table made from pie chart.

Prescribing pattern of drugs in patients with alcoholic liver disease in a tertiary care teaching hospital

Genova and coworkers [97] had shown that mitocondrial complex I is involved both in initial generation of superoxide and in the reduction of adrenochrome to its semiquinone form.

Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress

At the first meeting in 1952 of the Saskatchewan Committee for Schizophrenia Research, Duncan Hutcheon told us that discoloured adrenalin contained the red-pigmented oxidation product adrenochrome. The adrenochrome hypothesis of schizophrenia followed.

Othomolecular medicine: could medicinal chemistry be applied in an unconventional way to ease the suffering of schizophrenics?

For example, it has been proposed that in oxidative lesion of the myocardial ischemia-reperfusion, it occurs the epinephrine autooxidation in adrenochrome, associated with [O.sub.2] formation.

El deporte como causa de estres oxidativo y hemolisis / Sports as a cause of oxidative stress and hemolysis

It did not cover, for example, adrenochrome, featured in the film Fear and Loathing in Las Vegas.

Not all dangerous drugs are classified illegal

Hoffer's theory of the illness is that, under stress, schizophrenics produce an excess of adrenochrome, which is derived from adrenaline, and that adrenochrome can produce hallucinations and personality changes.

No poster boy

Dobutamine can be oxidized to adrenochrome, which produces a bright pink color (Eli Lilly, technical information on file); oxidation of dobutamine by peroxide /peroxidase, however, has not been described.

Mechanisms of dopamine and dobutamine interference in biochemical tests that use peroxide and peroxidase to generate chromophore

The increase in absorbance of adrenochrome was monitored at 25[degrees]C for 3 min at [lambda]=480 nm.

Xanthine oxidase activity in patients with age-related cataract associated with hypertension

This method is based on the inhibition of autoxidation of epinephrine to its adrenochrome. A mixture of 580 [micro]L PBS, 200 [micro]L of each extract or standard, and 200 [micro]L of liver, kidney, kidney, and heart homogenate and 20 [micro]L of inducing solution was introduced into different test tubes and incubated at 37[degrees]C for 1h.

Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate-Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model

This oxidation generates adrenochrome, which is measured at 480 nm with a spectrophotometer (24).

Leptin improves sperm cryopreservation via antioxidant defense

Hoffer observed that schizophrenic patients abnormally metabolized adrenaline (epinephrine) into an oxidized byproduct that he called adrenochrome. He learned that adrenochrome was capable of having hallucinatory effects much like mescaline and LSD.