The Tritonia diomedea swim afferent neurons
may use glutamate as their neurotransmitter.
Cardiac afferent neurons
express ASIC3 that are activated by mild acidification during ischemia [132, 133].
Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons
. Neuroscience 2014; 277: 679-89.
[N.sub.inf] represents predominantly A[delta] afferents and C-neurons (slowly conducting fibers that are specified as nociceptors), while [N.sub.0] represents A[alpha]/[beta] afferent neurons
(intermediate conducting fibers associated with mechanoreceptors) (22,24,25).
Nociceptive pain is defined as pain resulting from the on-going activation of primary afferent neurons
by noxious stimuli (McCaffery & Pasero, 1999).
This analgesic function is due to its capability of depleting substance P stores from the primary afferent neurons
, eventually relieving pain in conditions like peripheral arthritis.
Hyperpolarizing potentials have been described in the squid stellate ganglion (Miledi, 1972), in secondary hair cells and afferent neurons
of the squid statocyst (Williamson, 1989), and in central neurons of the cuttlefish (Chrachri and Williamson, 2003).
Furthermore, several studies have shown that the arbours of small-diameter primary C-fibre afferents can enlarge greatly in rats and mice after SCI potentially leading to increased reflex excitation of preganglionic neurons, via interneuronal pathways.[sup.15] These afferent neurons
are CGRP-immunoreactive, and are believed to mediate the spinal reflex pathways to the sympathetic preganglionic neurons, and hence play a significant role in the pathogenesis of NDO.[sup.11,15]
Descending spinal noradrenergic and serotonergic neurons inhibit the neurotransmitters noradrenaline and serotonin, released from primary afferent neurons
and dorsal horn neurons.
Receptor localization in the mammalian dorsal horn and primary afferent neurons
. Brain Research, Brain Research Reviews, 24(1), 28-66.
In addition, afferent neurons
may synapse with other afferent nerve cells within the central nervous system.