agglutinin


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Related to agglutinin: cold agglutinin

Agglutinin

A substance that will cause a clumping of particles such as bacteria or erythrocytes. Of major importance are the specific or immune agglutinins, which are antibodies that will agglutinate bacteria containing the corresponding antigens on their surfaces. Agglutinins are readily determined, and their presence is of diagnostic value to indicate present or past host contact with the microbial agent sufficient to result in antibody formation. See Agglutination reaction, Antibody

Analogous reactions involve erythrocytes and their corresponding antibodies, the hemagglutinins. Hemagglutinins to a variety of erthyrocytes occur in many normal sera, and their amounts may be increased by immunization. The blood group isoagglutinins of humans and animals are important special cases which must be considered in all proposed blood transfusions lest transfusion reactions result. See Blood groups

agglutinin

[ə′glüt·ən·ən]
(immunology)
An antibody from normal or immune serum that causes clumping of its complementary particulate antigen, such as bacteria or erythrocytes.
References in periodicals archive ?
A new test for the detection of weak and 'incomplete' Rh agglutinins. British J Exp Pathol.
pneumoniae infection is diagnosed by serological antibody tests, including a complement fixation test, passive agglutination test, and indirect agglutinin test, either alone or in combination [12].
Unfortunately, although they are generally considered a low glycemic index food, in our study, the islet cell antigens reacted with garbanzo bean, lima bean, gluten-free soy sauce, soy bean oleosin, soy bean agglutinin, tofu, pea lectin, pea protein, cooked pea, and cooked lentil.
A mannose-specific lectin from onion (Allium cepa agglutinin, ACA) also showed mitogenic activity in murine thymocytes, as well as a high production of IFN[gamma] and IL-2.
TNT009 is currently in clinical development for the treatment of Cold Agglutinin Disease (CAD), a rare disease in hematology.
The number of DBA-positive cells at different concentrations of fetal bovine serum groups FBS concentration (%) Times Average number of positive DBA 0 3 1.33 [+ or -] 0.58 (c) 1.5 3 7.67 [+ or -] 1.53 (b) 2.5 3 12.00 [+ or -] 2.22 (a) 3.5 3 8.67 [+ or -] 1.53 (b) DBA, Dolichos biflorus agglutinin; FBS fetal bovine serum.
The lectin-NPs tracers coated with Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Nonintegrin, Phaseolus vulgaris agglutinin-erythroagglutinin, soybean agglutinin, Sambucus nigra agglutinin, peanut aggluttin, Vicia villosa lectin (VVL), Aleuria aurantia lectin, Trichosanthes japonica agglutinin and Helix pomatia agglutinin exhibited strong preference for the Pla-CA125 antigen.
The lectin, wheat germ agglutinin (WGA), which was conjugated with Alexa Fluor 488 (Life Technologies Co.), was used for staining of mucus and some epithelial cells in the gills.
Drawing on their prior study showing increased sialylation of anti-TF antibodies in gastric cancer, they assessed the following: (1) serum levels of anti-TF antibodies by ELISA; (2) reactivity of anti-TF antibodies to Sambucus nigra agglutinin (SNA); (3) avidity of anti-TF antibodies by ELISA; and (4) avidity of SNA-reactive anti-TF antibodies in 104 patients and 49 controls.
Yegorenkova et at (20) have reported that Azospirittum brasitense might be involved in the recognition and cross-linking between wheat germ agglutinin and bacterial polysaccharide during the colonization on wheat roots.
The lower molecular weight of unreduced samples in comparison with reduced ones suggests the presence of intrachain disulfide bonds, as have been described previously in other lectins as ECA (Euphorbia calcina agglutinin) and EDA (Euphorbia dalberi agglutinin) or Euticurallin (Nsimba-Lubaki et al.