agglutinin


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Related to agglutinin: cold agglutinin

Agglutinin

A substance that will cause a clumping of particles such as bacteria or erythrocytes. Of major importance are the specific or immune agglutinins, which are antibodies that will agglutinate bacteria containing the corresponding antigens on their surfaces. Agglutinins are readily determined, and their presence is of diagnostic value to indicate present or past host contact with the microbial agent sufficient to result in antibody formation. See Agglutination reaction, Antibody

Analogous reactions involve erythrocytes and their corresponding antibodies, the hemagglutinins. Hemagglutinins to a variety of erthyrocytes occur in many normal sera, and their amounts may be increased by immunization. The blood group isoagglutinins of humans and animals are important special cases which must be considered in all proposed blood transfusions lest transfusion reactions result. See Blood groups

agglutinin

[ə′glüt·ən·ən]
(immunology)
An antibody from normal or immune serum that causes clumping of its complementary particulate antigen, such as bacteria or erythrocytes.
References in periodicals archive ?
Fulminant autoimmune cold-type hemolysis with marked elevation of monothermic cold agglutinins.
A new test for the detection of weak and 'incomplete' Rh agglutinins.
In our study, the Tn antigen recognizing lectins, Helixpomatia agglutinin and VVL did not bind to OvCa-CA125, indicating that in OvCa-MGL was not binding to Tn-antigen but likely to sialyl Tn antigen or the LacdiNAc.
the agglutinins depleted their activity by binding to the bacterial particles but increased the PA at the same time.
Transgenic rice expressing Allium sativum leaf agglutinin (ASAL) exhibits high-level resistance against major sap-sucking pests.
1982) Clones from cultured B16-mouse melanoma cells resistant to wheat germ agglutinin and with altered production of mucin-type glycoproteins.
Then slides incubated with Ulex europaeus agglutinin (UEA-I) and peanut agglutinin (PNA) peroxidase conjugated lectins at room temperature for 2 hr, were washed in PBS solution for 20-30 min, then placed in DAB-[H.
Particles of an antigen will only clump together in the presence of the specific agglutinin to that antigen.
Cell-type-specific expression of a wheat-germ agglutinin gene in embryos and young seedlings of Triticum aestivum.
Q When preheating a specimen with a severe cold agglutinin does not work (i.
h) Cold Agglutinin Disease (CAD) is an autoimmune disease characterised by the presence of high concentrations of circulating antibodies, usually IgM, dirested against red blood cells.