To answer whether ruminants can cleave plant specific metabolites like glycosides to the respective aglycon
, the metabolism of glucoside conjugates was investigated.
Chemically, flavonoids are polyphenols conjugated to sugars (as a glycosylated form) although some can exist as free aglycones
. The basic flavonoid structure is the flavan nucleus consisting of a 15-carbon skeleton arranged in two phenyl rings bound by a three-carbon bridge commonly encircled by oxygen, then forming three rings (Figure 1) .
The present method could pave the way towards the glycosylation of acid labile oligosaccharides as well as acid labile aglycon
palmitoyl group as aglycon
moiety) at position C-4 instead of position C-3 of methyl [alpha]-L rhamnopyranoside (2).
The efficiency of inhibition strongly depends on the structure of aglycon
and generally increases for [beta]-glucosidases with increase of its lipophilicity.
Regarding the effect of the neomycin, the results showed increase in the hematological parameters in the rats pretreated by neomycin and this may be due to its bactericidal effect on the microorganisms which hydrolyzes vicine to its toxic aglycon
Gil Mor of the Yale School of Medicine said that in addition to lomaiviticin aglycon
, Herzon's team also created smaller, similar molecules that have proven extremely effective in killing ovarian stem cells.
The concentration of quercetin was mainly due to the presence of quercetin metabolites rather than its aglycon
as recently revised by Murota and Terao (51).
Fortunately, there are other ginsenosides that are non-glucose-formed (aglycon
) and these are some of the compounds that appear to have the strongest anti-cancer activity.
Vancomycin is a cup-shaped molecule consisting of two sugars attached to a larger complex of amino acids known as the aglycon
. In October 1998, a team led by K.C.
3) Because of the absence of aglycon
(cyanidin), the activity of glucosyl-3-transferase (Glu3T) is very high (100%).
These four major flavones: glycoside baicalin (BG, MW; 446.37, [C.sub.22][H.sub.18][O.sub.11]), wogonoside (WG, MW; 460.39, [C.sub.22][H.sub.20][O.sub.11]), aglycon
baicalein (B, MW; 270.24, [C.sub.15][H.sub.10][O.sub.5]), and wogonin (W, MW; 284.27, [C.sub.16][H.sub.12][O.sub.5]) were reported to be the main bioactive components in S.