Low-dose isoflavone aglycone
alleviates psychological symptoms of menopause in Japanese women: a randomized, double-blind, placebo-controlled study.
Naringenin (5, 7, 4'-trihydroxyflavanone) presents predominantly in grapefruit, sour orange and tomatoes which can be present both aglycone
and glycoside form.
TDA of oleuropein and oleuropein aglycone
indicated that these compounds are bitter at a concentration of 50 [micro]g per 1 cm paper square .
Compounds 1 and 2 are glucosides, 3 and 4 are methoxy aglycones
, compounds 5 and 6 are glucuronides, and compounds 8-10 are aglycones
Meanwhile, it is shown that Epimedium flavonoids could be hydrolyzed into secondary glycosides or aglycone
by intestinal flora or enzymes, thereby enhancing their absorption and antiosteoporosis activity .
The electrons in EP were concentrated in the tetracyclic quinolid aglycone
, especially in the C ring.
Among tested compounds, the flavone aglycone
apigenin exhibited by far the strongest effect on XOD in vitro.
Pharmacological effect of triterpene glycosides is connected with the aglycone
whereas glycones are responsible for solubility of the molecules in water and influence the absorbability and penetration through the membranes .
Since gastric juices and digestive enzymes in the intestine were unable to hydrolyzed stevioside, they were hydrolyzed to aglycone
for absorption by the colon microflora at the lower intestinal tract.
It should be recognized that BPA-G can be back-converted to BPA (aglycone
) thanks to the ubiquitous presence of [beta]-glucuronidases in many organs and bodily fluids (Sperker et al.
Antioxidant Activities of The Flaxseed Lignan Secoisolariciresinol Diglucoside, Its Aglycone
Ecoisolariciresinol And The Mammalian Lignans Enterodiol And Enterolactone In Vitro.