ajmaline


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ajmaline

[′aj·mə‚lēn]
(organic chemistry)
C20H26N2O2 An amber, crystalline alkaloid obtained from Rauwolfia plants, especially R. serpentina.
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What does it do: Yohimbe has been recognised as a sexual stimulant for centuries; it contains a number of indole alkaloids such as ajmaline, corynanthene and yohimbine; it is the latter chemical that has attracted the attention of the American and European drug companies.
Police said that the killer had used five different drugs including ajmaline, sotalol, lidocaine, amiodarone and calcium chloride.
Definitive diagnosis requires administration of the ajmaline challenge test (a sodium channel blocker to unmask the ECG changes of subclinical BrS).
published the catheter ablation of Brugada syndrome with endpoints of elimination of all abnormal electric ventricular potentials before and after ajmaline, leading to ECG normalization and noninducibility of VT/VF [7].
Electrocardiogram showed typical BrS findings in the third costal position during the ajmaline test; however, simultaneous ECG in the fourth costal position was completely normal (Figure 2a, b).
The diagnostic electrocardiographic aspect can be unmasked with the class IC antiarrhythmic drug test (ajmaline is considered the best option, particularly because of its short half time life) [3].
Categories Substance with HILI Alkaloids Aconitine; febrifugine; ajmaline; vincristine Glycosides Cardiac glycosides; cyanogenic glycosides; saponins; bulbifera Toxic proteins toxin fruit; croton, castor; abrinjatropha; trichosanthes; centipede; snake venom; viper Terpene and Toosendan; spurge; Coriaria leaf; wormwood lactones leaves Tannins Gall; peel; holly leaf Heavy metals Cinnabar; realgar; light powder; litharge; vitriol; red lead Other toxic Garcinia; red fennel root; Hydnocarpus, components Pinellia ternata; daphne; melon pedicle acids; Asarum; rue; mint; Asarum forbesii; musk grass
Molecule in cMap Enrichment score P value Isoflupredone -0.928 0.00054 Trihexyphenidyl -0.922 0.00080 Prestwick-691 -0.856 0.00599 Ajmaline -0.834 0.00903 Carteolol -0.754 0.00734 Thiamphenicol -0.672 0.00883 DL-thiorphan 0.942 0.00632 Milrinone 0.903 0.00182 Apigenin 0.873 0.00036 Ronidazole 0.852 0.00611 Skimmianine 0.835 0.00115 Chrysin 0.826 0.01064 Rottlerin 0.825 0.01074 Clomipramine 0.787 0.00400 Deptropine 0.783 0.00412 Sulconazole 0.783 0.00416 Ethaverine 0.741 0.00863 Ketanserin 0.727 0.01110 Prestwick-685 0.670 0.01045 Resveratrol 0.536 0.00558
tetraphylla is regarded as a rich source of different types of important alkaloid constituents such as reserpine, deserpidine, reserpiline, raujemidine, isoreserpiline, ajmaline, ajmalicine, yohimbines, serpentine, tetraphylline, sarpagine and vellosimine (Haack et al., 1954; Mukherjee, 1961;).
The condition is diagnosed by injecting patients with a drug called ajmaline which shows up changes in people with Brugada.
Drugs known to cause LIBD include neuroleptic agents (chlorpromazine, imipramine, carbamazepine, amitriptyline, haloperidol, cyproheptadine, and phenytoin), antibiotics (amoxicillin, flucloxacillin, quinolones, clindamycin, macrolides, and tetracyclines), complementary and alternative medicines (ajmaline and glycyrrhizin), nonsteroidal antiinflammatory drugs (diclofenac and ibuprofen), amiodarone, cimetidine, thiabendazole, and zonisamide, among others.