aldol reaction


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aldol reaction

[′al‚dȯl rē′ak·shən]
(organic chemistry)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Previously [24], we found the B3LYP/6-31G(d) [41, 42] method as a good tool for investigating the stereoselectivity in the aldol reaction of the bicyclic amino ketones in the presence of water.
At first glance, the reaction parameters obtained from our computational approach, at 6-31g(d) level (but also at 6-311++g(3d,3p) vide infra), calculated along the lines used for aldol reaction of acetone by Zhang and Houk [26], that is, the reaction of tropinone and granatanone enols with benzaldehyde, totally disagreed with experiment.
Brindle, "The direct catalytic asymmetric aldol reaction," Chemical Society Reviews, vol.
Beletskaya, "Organocatalysis of asymmetric aldol reaction. Catalysts and reagents," Russian Chemical Reviews, vol.
Mlynarski, "Direct asymmetric aldol reaction of hydroxyacetone promoted by chiral tertiary amines," Tetrahedron Letters, vol.
Kalicki, "Diastereo- and enantioselective aldol reaction of granatanone (pseudopelletierine)," Tetrahedron, vol.
Using these proline amides and pyridinium salts as catalysts in aldol reaction is also important from the viewpoint of green chemistry, because of using environmentally friendly solvent water.
The aldol reactions of acetone with various aromatic aldehydes were carried out in water by using proline amide derivatives and pyridinium salts derived from chiral pyridine derivatives for the first time.
Keywords: Aldol reactions, Green chemistry, Homogeneous catalysis, Phase-transfer catalysis, Proline amides, Pyridinium salts.
Then, the aldol reactions of acetone with several aldehydes with or without the catalysts 6, 7 and 8 in water were investigated.
General Procedure for Aldol Reactions withCatalysts 11 and 12
Duthaler spoke about the use of cyclopentadienyltitanium-TADDOLS to mediate enantioselective additions of organolithium species to carbonyls and to effect aldol reactions as well as additions of allyl titanium species to carbonyls.