Aldolase


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aldolase

[′al·də‚lās]
(biochemistry)
An enzyme in anaerobic glycolysis that catalyzes the cleavage of fructose 1,6-diphosphate to glyceraldehyde 3-phosphate; used also in the reverse reaction.

Aldolase

 

an enzyme; one of the lyases, which split and synthesize carbon bonds (—C—C—). Its molecular mass is 147,000–180,000; the aldolase molecule is composed of two polypeptide chains. In animals aldolase is generally found in the skeletal muscles; in plants it is found in areas where photosynthesis takes place. Aldolase condenses aldehydes; this is the derivation of the name. It is catalyzed by a reversible reaction: fructose diphosphate ⇌ 3–phosphoglycerine aldehyde + phosphodioxyacetone. In plant tissues aldolase takes part in the dark phase of photosynthesis; in animals, in the process of glycolysis, which leads to the production of such energy-rich compounds as ATP.

References in periodicals archive ?
When aldolase activity is low, in most cases sugars and starches accumulate in Zn deficient plants.
In addition, we also found nine genes that play a central role in the upper progression path of Figure 1(a), i.e., two DNA repair-related genes (histone cluster 2 (H2be; HIST2H2BE) and replication factor C5 (RFC5)), four apoptosis-related genes (heat shock 27-kDa protein 1 (HSPB1), zinc finger protein 480 (ZNF480), tubulin alpha 1c (TUBA1C), and ribosomal protein L30 (RPL30)), and three metabolism-related genes (aldolase B (ALDOB), frequently rearranged in advanced T-cell lymphomas 2 (FRAT2), and tRNA methyltransferase 1 (TRMT1)).
She was diagnosed as having JIIM based on clinical muscle weakness (manual muscle testing-8 score: 68 (range 0-80)), mildly elevated levels of muscle-derived enzymes (creatine kinase, 196U/L; aldolase, 13.6IU), the findings on muscle MR imaging, slightly high-signal intensity in the thigh with T2-weighted fat suppression, and skin biopsy.
tuberculatum venom can be grouped basically into proteins involved in insect metabolism (annexin B9, nucleoside diphosphate kinase; aconitate hydratase; superoxide dismutase; triose phosphate isomerase; glyceraldehyde-3phosphate dehydrogenase; succinyl-CoA ligase; fructosebisphosphate aldolase; arginine kinase; citrate synthase; enolase; ATP synthase; 4-hydroxybutyrate coenzyme A transferase; medium-chain specific acyl-CoA dehydrogenase, and isocitrate dehydrogenase); transport protein (transferrin); and structural proteins (cyclophilin, actin, and chitinase).
Laboratory examination revealed slight elevations in white blood cell count (11,900/[micro]l), serum C-reactive protein concentration (2.65 mg/dl), and aldolase level (7.1 U/l).
Further enzymatic reactions involving a specific aldolase and a dehydrogenase (4-N-trimethylaminobutyraldehyde dehydrogenase, TMABA-DM) convert 3-hydroxy-trimethyllysine to [gamma]-butyrobetaine.
These include earlier and increased protein synthesis, aldolase, and isocitrate lyase activity and greaterglucose-6-phosphate dehydrogenase and decreased alcoholdehydrogenase activity in primed sweet corn and sunflower seeds, leading to improved reservemobilization (Wahid et al.
Inverness Medical Professional Diagnostics, Scarborough, ME, USA) for malaria was positive for aldolase but negative for histidine-rich protein 2.
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.
On Day 2, the patient's serum myoglobin level was 14,301 ng/mL (normal range, 30-90 ng/mL) and her aldolase level was 87.6 U/L (normal range, 1.5-8.5 U/L).
Type 2 PH and Type 3 PH are due to impairment of glyoxylate reductase/hydroxyl pyruvate reductase (GRHPR) and 4-hydroxy-2-oxaloglutarate aldolase (HOGA1), respectively (Edvardsson et al., 2013).
Foi coletado dos prontuarios dos jogadores dados como idade, peso corporal, estatura e exames bioquimicos de calcio, calcio ionico, fosforo, magnesio, potassio, sodio, aldolase, alanina aminotransferase (ALT), aspartato aminotransferase (AST), CK, lactato desidrogenase (LDH), creatinina e ureia no periodo de janeiro, maio e agosto de 2015 e janeiro de 2016.