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alizarin (əlĭzˈərĭn), or 1,2-dihydroxyanthraquinone, mordant vegetable dye obtained originally from the root of the madder plant (Rubia tinctorum), in which it occurs as a glucoside. The term also includes a group of synthetic dyestuffs prepared from coal-tar derivatives. A method for the synthesis of alizarin was first discovered (1868) by Karl Graebe and Karl Liebermann, German chemists. With salts of metals the compound forms brilliant lakes, although by itself it is a poor dye. Turkey red is produced with an aluminum mordant, other shades of red with calcium and tin salts, dark violet with iron mordants, and brownish red with chromium. Purpurin, also used in dyeing, occurs with alizarin in madder and is produced synthetically.
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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a dye in the form of orange crystals slightly soluble in water and readily soluble in aqueous alkalis; its melting point is 289°C.

Alizarin is found in the roots of the madder plant (Rubia tinctorum), extracts of which were used for dyeing as long ago as ancient times in Egypt, Persia, and India. Known as alizari, madder roots were imported to Europe from Eastern countries. Beginning with the second half of the 18th century, the madder was cultivated in the Crimea and the Caucasus. The dye was first obtained from the plant in 1826 by the French chemists P. Robiquet and J. Colin. Later, in 1869, the German chemists K. Graebe and K. T. Lieber-mann deduced the structure of alizarin and synthesized it for the first time. Cultivation of the madder came to an end when synthetic alizarin became cheaper than the natural product. Synthetic alizarin began to be produced in Russia in 1874 (in the city of Kirzhach).

Alizarin belongs to the class of mordant anthraquinone dyes. With the salts of certain polyvalent metals, alizarin forms colored complex compounds, the so-called lakes, which bond firmly with textile fibers. The most widely used compound of alizarin with aluminum is of bright red color; with iron, of violet color; and with chromium, of brown color.

Alizarin is scarcely used any longer as a textile dye, since it is inferior in quality to many other dyes and more expensive as well. However, it is used as an intermediate product in the synthesis of other dyes; for example, aluminum madder lake is used in the preparation of paints for artists, as well as in polygraphy.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


(organic chemistry)
C14H6O2(OH)2 An orange crystalline compound, insoluble in cold water; made synthetically from anthraquinone; used in the manufacture of dyes and red pigments.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Vital staining with alizarin red and the use of optical microscopy is a quick, simple and inexpensive technique for obtaining images for evaluation of the endothelium of animals and humans (TAYLOR; HUNT, 1981; SAAD et al., 2008; FAGANELLO et al., 2016).
(9) The ability of the BMSCs to differentiate into osteoblasts was confirmed based on the presence of calcium phosphate and Alizarin Red staining.
Panconesi, "Rubia tinctorum a source of natural dyes: agronomic evaluation, quantitative analysis of alizarin and industrial assays," Industrial Crops and Products, vol.
Adipocytes were stained with oil red O, and osteoblasts were stained with alizarin red S.
(a) Calcification deposition in MC3T3-E1 cells was determined using Alizarin Red staining.
Isolated En-MSCs of the goat endometrium were differentiated to chondrocytes, osteocytes, and adipocytes, and this differentiation was confirmed by staining with the Alcian blue, Alizarin red, and Oil Red O, respectively.
At day 84, all mice subjected to the HPD developed phosphate nephropathy with tubular calcium hydroxyapatite crystals, which was stained positive with alizarin red.
Our results showed that interestingly HAp coating did not significantly increase osteogenecity (Alizarin Red production) in vitro and noncoated Ti scaffolds were also osteoinductive.
Se reviso literatura sobre el tema en las bases bibliograficas electronicas PubMed, Google Academico y SciELO, a partir de la metodologia PRISMA [30], a traves de la asociacion del termino double staining con los descriptores en salud del Medical Subject Headings (MeSH) alizarin red, alcian blue, bone y cartilage, y la combinacion con los operadores boleanos + y &.
Alizarin, from the madder plant, is also a very old red, but wasn't introduced to Europe until the 13th century.
At the end of the third week, osteogenic differentiation was evaluated with Alizarin Red staining (Sigma, USA).