Acute Hypocalcemia and Metabolic Alkalosis
in Children on Cation-Exchange Resin Therapy.
Of note, only one patient had a pre-dialysis serum tC[O.sub.2] level slightly higher than 26 mEq/L, allowing us to conclude that none of our patients had unsafe levels of metabolic alkalosis
pointed out in previous studies (8,9,18,19).
Laboratory investigations showed hypokalaemia (2.5 Meq/L), shypochloraemia (64 Meq/L) and metabolic alkalosis
. Since there was history of unexplained polyhydramnios along with hypokalaemia, hypochloraemia and metabolic alkalosis
,neonatal Bartter syndrome was suspected.
Other genetic syndromes, such as Bartter's or Gitelman's, cause hypokalaemia with alkalosis
but without hypertension.
A recent study from our research group has demonstrated that a 14-d supranutritional antioxidant supplementation (100 IU/kg VE plus 1.2 ppm selenium) could not only mitigate oxidative stress, but also effectively ameliorate the respiration rate and respiratory alkalosis
in heat-stressed sheep , suggesting that a short-term supranutritional antioxidant supplementation effectively mitigate the HS-induced oxidative stress and exhibit a novel function in maintaining acid-base balance.
For practical purposes, all acid-base disturbances are referred to as "acidosis or alkalosis
", without making any distinction with regard to the terms "acidemia and alkalemia".
Lab-analysis showed the following: normal renal, hepatic, and thyroid function; normal coagulation tests; normal white cell and platelet count; mild normocytic anemia (Hb = 10 g/dl); metabolic alkalosis
associated with severe hypokalemia.
was noted to be chloride resistant (urine chloride of >20mEq/dl).
 reported a series of eight patients with atypical genetically determined Bartter syndrome type 1, including absence of nephrocalcinosis, absence of hypokalemia, and/or metabolic alkalosis
in the first year of life as well as persistent metabolic acidosis mimicking distal renal tubular acidosis.
Normal calcium, phosphorous, and magnesium levels were found, while there were high creatine phosphokinase levels (1029 U/L) and metabolic alkalosis
. Thyroid function tests were in normal limits.
ABG (arterial blood gas) revealed raised lactate (2.3 mmol/L), respiratory alkalosis
Animals with mechanical obstruction are at risk for hypokalemia, hyponatremia, hypochloremia, metabolic acidosis and metabolic alkalosis
(Mishra et al., 1974).