Homogentisic Acid

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Related to alkapton: alkaptonuria, homogentisic acid

homogentisic acid

[¦hä·mə‚jen¦tiz·ik ′as·əd]
C8H8O4 An intermediate product in the metabolism of phenylalanine and tyrosine; found in excess in persons with phenylketonuria and alkaptonuria.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Homogentisic Acid


an intermediate product of the decomposition of the cyclic amino acids phenylalanine and tyrosine in the animal or human body. In the hereditary disease alkaptonuria, which is expressed in a disturbance of the metabolism of these amino acids, the process stops at the stage of homogentisic acid formation because of an absence of homogentisic acid oxidase, and homogentisic acid is discharged with the urine.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.