alkylate

(redirected from alkylating)
Also found in: Dictionary, Medical.

alkylate

[′al·kə‚lāt]
(organic chemistry)
A product of the alkylation process in petroleum refining.
References in periodicals archive ?
These three patients with multiple myeloma and ESRD were treated with alkylating agents and autologous HSCT; each had prolonged infection and developed severe SOS in case 1, very severe SOS in case 2, and moderate SOS in case 3 based on proposed grading of SOS severity by EBMT criteria [1] (Table 1).
By tracking this observation, we discovered that if the original alkylating agent was omitted from the reaction, employing instead more than a stoichiometric amount of TEBAC, a clean transfer of a unique benzyl group took place.
The purine-like structure of these reductive alkylating agents may permit selective inactivation of purine-utilizing enzymes in low reduction potential tumor cells.
Six momarsa for the supply of (a) cancer medicines (tablets), (b) chemicals & requisites for the Pathology Unit, (c) cancer medicines (alkylating agents), (d) earphones to fix behind the ear, (e) cancer medicines (planet alkaloids), and (f) medical requisites for the Urology Unit.
Their topics include human biotransformation, analytical tools and approaches for metabolic identification in drug metabolism, the unanticipated loss of N2 from novel DNA alkylating agent laromustine by collision-induced dissociation, and strategies for detecting reactive intermediates in drug discovery and development.
Titled "Bendamustine: A Novel Cytotoxic Agent for Hematologic Malignancies," it notes that bendamustine hydrochloride has a chemical structure containing alkylating nitrogen mustard, contributing to its cytotoxic properties.
Overall, the literature suggests that 34% of females who undergo chemotherapy develop ovarian failure, though alkylating agents such as cyclophosphamide are four times as toxic to the ovaries as other agents, Dr.
Currently, the drug is approved to treat the disease in patients that have been treated with an alkylating agent and have failed fludarabine therapy.
Osteoporosis is one such potential complication that can result from treatment with alkylating agents and the steroids that are often given with chemotherapy.
The drug is currently not approved for the treatment of multiple sclerosis but is indicated for treating B-cell chronic lymphocytic leukemia in patients who have been treated with alkylating agents and who have failed fludarabine therapy.
TEMODAL (temozolomide) Capsule is an oral, cytotoxic alkylating agent indicated for treating glioblastoma multiforme (GBM).