We have synthesized three new pyrroloimidazole by 1, 3 dipolar cycloaddition by using new alkylating agent
isopropyl bromoacetate with sulfur activated dipolarophiles.
This would include patients diagnosed with cancers known to require exposure to known gonadotoxic agents (such as high doses of alkylating agents
, as seen in cases of rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma, Hodgkin's lymphoma) or radiation to achieve cure (e.
21) Cyclophosphamide was chosen because it is platelet-sparing, readily available, and cost-effective, and because, like chlorambucil, it is an alkylating agent
At one TRC member institution, the Massachusetts Institute of Technology (MIT), researchers are focusing their attention on the effects of simple and complex alkylating agents
, a class of DNA-damaging environmental toxins and toxicants that cause cell death, mutations, birth defects, and cancer.
Predisposition to treatment-related AML is primarily due to chemotherapy with alkylating agents
(nitrogen mustard, cyclophosphamide, procarbazine) or epipodophyllotoxins (etoposide, teniposide) (Table 3).
Amifostine has demonstrated selective protection of some types of normal tissue when administered with several antineoplastic drugs, including cisplatin, carboplatin, mitomycin and alkylating agents
Cell lines from patients with Alzheimer's disease (AD) are hypersensitive to the cell-killing effects of ionizing radiation and alkylating agents
|4, 7-9~, but not to the cell-killing effects of UV light.
Combinations of corticosteroid with alkylating agents
or calcineurin inhibitor (CNI) have been proved to be effective to induce remission of PMN with persistent heavy proteinuria.
We also offer it to patients who are at extremely high risk for going through ovarian failure or infertility, like patients who need to get transplants or those who receive high doses of alkylating agents
The purine-like structure of these reductive alkylating agents
may permit selective inactivation of purine-utilizing enzymes in low reduction potential tumor cells.
The anti-neoplastic agent can be an alkylating agent
, an antibiotic agent, an antimetabolic agent, a retinoid, a hormonal agent, a plant-derived agent, an anti-angiogenesis agent and a biologic agent such as monoclonal antibody and interferon.
Apaziquone is a novel anticancer drug that is activated, to become a cytotoxic alkylating agent
, through bio-reductive enzymes, such as DT-diaphorase, that are over-expressed in bladder cancer cells.