A SLIT combination of Timothy pollen and nine additional pollen allergen extracts
performed significantly worse than Timothy alone at the same dose; in fact, it failed to outdistance placebo in most endpoints (J.
Multiple allergen extracts
are tested simultaneously on the same patient.
The blocking activity of the allergen-specific IgG fraction on the IgE reactivity to Dpt allergen extract
was then evaluated by inhibition ELISA.
Activated, washed microspheres were suspended in 50 [micro]L of diluted allergen extract
(1:100 in PBS, pH 7.4).
Efficacy and safety of sublingual tablets of house dust mite allergen extracts
in adults with allergic rhinitis.
A study reported that the development of sensitisation to perennial allergens early in life (3mm at the SPT.9 Allergen extracts
for SPT were procured from abroad (Greerlabs, USA) and included allergens of HDMs, paper mulberry, grass, mixed pollen, neem and eucalyptus, cannabis, dandelion, ragweed, bottle brush, cockroach, cat and dog hair, wasp and pigeon feathers, Candida albicans, Alternariaalternata and Aspergillus fumigatus.
SIT can be improved by using recombinant allergens, which contain most of the IgE-binding epitopes of the source allergens and are pure and better standardized compared to natural allergen extracts
For allergen extracts
that are available as 1:20 wt/vol, the six dilutions contain an allergenic concentration of: 1:100 for dilution #1; 1:500 for dilution #2; 1:2500 for dilution #3; 1:12,500 for dilution #4; 1:62,500 for dilution #5 and 1:312,000 for dilution #6.
Current AIT with native allergen extracts
carries the risk of adverse reactions, since allergens in their native conformation present IgE epitopes and possess full allergenic potential.
in standard activity and concentration (Stallergenes SA, France) and multiple test applicators (10 tests/panel, Medikaperk Express, Istanbul, Turkey) were used for the SPT.
for SPT were purchased from Hollister Stier (Spokane, WA, USA).