alloantigen


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Related to alloantigen: alloantibody, autoantigen, isoantigen, heterophile antigen, heteroantigen, xenoantigen

alloantigen

[¦a·lō¦ant·i·jən]
(immunology)
References in periodicals archive ?
As initially proposed by Billingham in 1966,14 three conditions are required for the development of GVHD: (1) the graft must contain immunologically competent cells; (2) the host itself must be incapable of mounting an effective immunologic reaction against the graft; and (3) the host must possess important transplant alloantigens that are lacking in the donor graft so that the host appears foreign to the graft.
from the University of New SouthWales (Australia) showed that Th1 and Th2 responses promoted the development of two different pathways of alloantigen specific Tregs in vivo, depending on the cytokine milieu.
This has been attributed to transfusions of racially mismatched pRBCs, resulting in increased alloantigen exposure (8).