Association of a B cell alloantigen
with susceptibility to rheumatic fever.
As initially proposed by Billingham in 1966,14 three conditions are required for the development of GVHD: (1) the graft must contain immunologically competent cells; (2) the host itself must be incapable of mounting an effective immunologic reaction against the graft; and (3) the host must possess important transplant alloantigens
that are lacking in the donor graft so that the host appears foreign to the graft.
from the University of New SouthWales (Australia) showed that Th1 and Th2 responses promoted the development of two different pathways of alloantigen
specific Tregs in vivo, depending on the cytokine milieu.
Typing for human platelet alloantigens
. Rev Immunogenet 1999;1:239-54.
Kuns et al., "Conventional dendritic cells are the critical donor APC presenting alloantigen
after experimental bone marrow transplantation," Blood, vol.
(3) The very rare allele 4 (gene frequency < 0.01) uniquely expresses 2531T, which defines the [Sit.sup.a] alloantigen
. Within the coding sequence, 2 single-point missense dimorphisms have been described: A1648G (Lys505Glu) and C2531T (Thr799Met) are responsible for the formation of the [Br.sup.a]/[Br.sup.b] (HPA-5) and [Sit.sup.a] alloantigens
NK1.1 is a marker of natural killer (NK) cells and an alloantigen
whose expression is limited to NK cells in several mouse strains [58, 59].
The effect of human platelet alloantigen
polymorphisms on the in vitro responsiveness to adrenaline and collagen.
The direct pathway of alloantigen
recognition is unique to transplantation.
The orchestrated response of innate and adaptive immune cells against the alloantigen
is highly dependent on directed migration and homing of immune cells to the lymphoid tissues and site of inflammation .
Stastny, "Identification of MICA as a new polymorphic alloantigen
recognized by antibodies in sera of organ transplant recipients," Human Immunology, vol.
Yokoyama, "MHC class I alloantigen
specificity of Ly-49+ IL-2-activated natural killer cells," Nature, vol.