allodynia


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allodynia

[‚a·lə′dī·nē·ə]
(medical)
Painful response to a stimulus that does not normally elicit pain.
References in periodicals archive ?
Intrathecal administration of minocycline, a selective inhibitor of microglial cell activation, inhibits low threshold mechanical allodynia (42, 47).
(10,11) Gabapentin was shown to decrease allodynia and hyperalgesia in inflammatory and neuropathic models of pain in both human and animal models.
Significant (P<0.05) reduction in paw pressure withdrawal threshold and cold allodynia in group 2 rats was observed when compared to control rats confirming reduced pain threshold levels (Figs 3 & 4), control group rats did not show any sign of recovery until 4 wk.
Spontaneous pain or allodynia / hyperalgesia occurs, is not limited to the territory of a single peripheral nerve, and is disproportionate to the original inciting event.
None of the patients had hyperalgesia or allodynia. Tendon reflexes were found to be normal in all patients.
Researchers reported Lidoderm produced significant improvement in pain relief and reduction in pain intensity and pain interference with quality of life in patients with allodynia and those without allodynia.
Spontaneous pain (hyperalgesia and allodynia) disproportionate to the inciting event
of treating cold allodynia, a condition in which people with nerve damage feel extreme pain from cool sensations, such as a breeze blowing across the skin.
Furthermore, photophobia and phonophobia were present in these patients at a higher rate, and allodynia was developed much more frequently when compared with migraineurs without autonomic manifestations (4).
Carlo demonstrated that low concentration of [O.sub.3] prevented the development of mechanical allodynia and decreased the overexpression of caspase 1, 8, and 12 in the orbitofrontal cortex in spared nerve injury (SNI) mice [15].
Moreover, an inflammatory response in the spinal cord causes central sensitization of the spinal cord as manifested by long-lasting thermal hyperalgesia and mechanical allodynia [4, 5].