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The condition of having an abnormally small number of platelets in the circulating blood.



a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
There is no increased risk of recurrence in subsequent pregnancy unless alloimmune thrombocytopenia is the cause which carries greater than >75% recurrence risk.
Long-term effects of fetal and neonatal alloimmune thrombocytopenia and its antenatal treatment on the medical and developmental outcomes of affected children.
348 cases of suspected neonatal alloimmune thrombocytopenia.
Alloimmune thrombocytopenia is one of the true success stories in maternal-fetal medicine, Dr.
Alloimmune thrombocytopenia is an important exception, however.
For the Medicine prize, Al-Othaimeen said Berkowitz and Bussel of the Columbia Medical Center, New York, worked together for more than two decades to study the natural history, optimal diagnostic criteria and management of pregnant women having fetuses infected with Alloimmune thrombocytopenia.
Herpes, Varicella, Neonatala Alloimmune Thrombocytopenia, Hemolytic Disease of the Fetus/Neonate