allopurinol


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Related to allopurinol: gout, colchicine

allopurinol

[‚a·lə′pyür·ə‚nȯl]
(pharmacology)
C5H4ON4 The compound 4-hydroxypyrazolo-3,4-d-pyrimidine; inhibits xanthine oxidase, an enzyme required for uric acid formation.
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The patients were then administered with 100 mg/day of allopurinol for 2 years.
Clinical trials conducted pre-approval showed an increased risk of heart-related problems, compared with allopurinol, and the drug label already carries a warning about cardiovascular events.
The FDA approval of Duzallo was based on the clinical program supporting the Zurampic (lesinurad) new drug application (NDA) and a pharmacokinetic study that evaluated the bioequivalence of the fixed-dose combination of lesinurad and allopurinol compared to co-administration of separate lesinurad and allopurinol tablets.
With DUZALLO, nearly twice as many patients with uncontrolled gout may be able to achieve target serum uric acid levels compared to those patients taking allopurinol alone, which is important, considering the significant unmet need among uncontrolled gout patients to get to goal of under 6 mg/dL, said Tom McCourt, senior vice president of marketing and sales and chief commercial officer at Ironwood.
Allopurinol is the most commonly used urate-lowering therapy worldwide, but concerns about adverse effects have inspired debates about dosing strategies for years, noted Dr.
At sixth hour of life, five foals from each group were randomly assigned to receive Allopurinol (Allopurinol 300mg, Medley Industria Farmaceutica LTDA, SP, BR.
Probenecid is a uricosuric agent and an alternative to allopurinol.
They were treated with 100-mg allopurinol 8 hourly in a day for 3 months.
Colchicine reduces gout attacks when combined with probenecid or allopurinol at the start of urate-lowering therapy (SOR: B, 1 high-quality and 1 low-quality RCT).