allopurinol


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Related to allopurinol: gout, colchicine

allopurinol

[‚a·lə′pyür·ə‚nȯl]
(pharmacology)
C5H4ON4 The compound 4-hydroxypyrazolo-3,4-d-pyrimidine; inhibits xanthine oxidase, an enzyme required for uric acid formation.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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However, in the United States febuxostat is more expensive than allopurinol. Also, a 2018 study found that although febuxostat was associated with similar rates of major cardiovascular events as allopurinol, the rate of deaths from cardiovascular disease and all causes was slightly higher in febuxostat-treated patients.
Although disputed by some investigators, early observations suggested that patients with CKD were more likely to experience allopurinol hypersensitivity, presumably owing to excessive allopurinol or oxypurinol serum levels.
Research has suggested that both febuxostat and allopurinol have similar efficacy.
Conclusion: Allopurinol was found to be more effective than febuxostatin reducing the left ventricular mass and left ventricular hypertrophy independent of blood pressure.
"A strategy of allopurinol dose escalation, which in current real-life practice is characterized by limited dose increases, is unlikely to improve the survival of patients with gout," the authors write.
The patient was diagnosed with allopurinol-induced DRESS syndrome in accordance with these clinical and histophatological findings, so the use of allopurinol was stopped immediately.
* Should the dosage of allopurinol be increased or should a non-xanthine oxidase inhibitor be initiated?
"I took the medicine for about 10 days (allopurinol and Maxigesic Paracetamols) but then I noticed some lumps on my throat which were very painful," she pointed to an area under her jaw, just below her ear, to show the exact spot.
In a modified intention-to-treat analysis at a median of 32 and maximum of 85 months of follow-up, the rate was 10.8% in the febuxostat group and similar at 10.4% in the allopurinol group.
These patients had been diagnosed with allopurinol-induced SCARs within the first 3 months of allopurinol exposure.
The patients were then administered with 100 mg/day of allopurinol for 2 years.