allostery

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allostery

[′a·lō‚stir·ē]
(biochemistry)
The property of an enzyme able to shift reversibly between an active and an inactive configuration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The results of the dynamic sensitivity analysis revealed that the metabolites in the methionine cycle behave stably as a result of perturbation to the enzymatic activity but have a possibility to oscillate in the absence of the allosteric regulation of CBS by AdoMet.
Apart from accounting for cooperative effects, their modified form also accommodated allosteric feedback inhibition, an important feature of many cellular reactions that M-M kinetics does not explain [7].
"We believe this work represents a breakthrough in designing synthetic allosteric agonists for chemokine GPCRs," said Thomas Sakmar, M.D., an author on the paper.
Depending on the [alpha] value, the binding of one substrate can favour ([alpha] < 1) or hinder ([alpha] > 1) the binding of the second substrate, leading to a positive or negative effect of allosteric cooperativity.
Gilliland, Positive and Negative Cooperativitics at Subsequent Steps of Oxygenation Regulate the Allosteric Behavior of Sebacyl-Hemoglobin, Biochemistry 35 (11), 3418-3425 (1996).
Clearly, the expression of proteins with the correct conformational and allosteric properties is essential for cells to perform their specific function(s).
Release date- 23082019 - BOSTON - HotSpot Therapeutics, Inc, a biotechnology company pioneering the discovery of nature's regulatory sites to advance allosteric drug discovery, today announced the acquisition of Macroceutics, Inc., a provider of DNA-encoded library (DEL) screening technologies.
Zulresso, the first medicine specifically approved by the US Food and Drug Administration (FDA) for the treatment of postpartum depression in adults, is a positive allosteric modulator of both synaptic and extrasynaptic GABAA receptors.
Treatment methods for glioblastoma have indicated no significant improvement for the last 15 years and the company serves to meet this unmet need through the development of allosteric modulators of an enzyme called LSD1.
According to the company, the SX-682 is a clinical-stage oral allosteric small-molecule inhibitor of CXCR1 and CXCR2 (CXCR1/2), a combined "master switch" of the immunosuppressive tumour microenvironment.
Reata Pharmaceuticals announced the initiation of a Phase 1 clinical trial of Reata's RTA 1701, a highly selective and orally bioavailable allosteric RORgammat inhibitor.