allostery

(redirected from allosteric)
Also found in: Dictionary, Medical, Wikipedia.
Related to allosteric: allosteric site

allostery

[′a·lō‚stir·ē]
(biochemistry)
The property of an enzyme able to shift reversibly between an active and an inactive configuration.
References in periodicals archive ?
We believe this work represents a breakthrough in designing synthetic allosteric agonists for chemokine GPCRs," commented Thomas Sakmar, M.
Accessing Captisol is a prime example of an early collaboration that will help accelerate the clinical development and commercialization of our broad pipeline of allosteric receptor modulators to treat debilitating CNS conditions such as schizophrenia, depression and traumatic brain injury.
Anvyl's drug discovery approach uses targeted allosteric modulation of ion channels to correct disease.
Anchor's peptides, called pepducins, modulate GPCR activity utilizing a unique intracellular allosteric mechanism that is well suited for a wide variety of targets, including intractable and orphan receptors.
SAGE Therapeutics' PANAM chemistry platform will enable the rapid development of novel allosteric receptor modulators that fine tune and balance the neuronal activity that is disrupted in these disorders.
Using this proprietary FRET screening assay, Celladon has developed a broad platform of novel, first-in-class, small molecule allosteric modulators of the SERCA2b enzyme - generating drug candidates targeting diseases associated with ER stress-related pathways such as diabetes and neurodegenerative diseases.
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development Maria Letizia Barreca, et al
Addex Therapeutics, a leading company pioneering allosteric modulation-based drug discovery and development, announced positive preclinical data for its mGlu5 negative allosteric modulator (NAM) oral small molecule, dipraglurant, in a validated rodent model of dystonia, a spectrum of disorders, that includes several rare diseases and is characterized by debilitating involuntary muscle contractions and body movements.
8 angstrom) of the adenosine a2a receptor in Science, which revealed new detail, including a previously unknown allosteric binding site.
The approach has enabled the advancement of numerous "stalled" programs by identifying new protein forms and novel binding sites including competitive and allosteric sites on enzymes and hotspots for protein-protein interactions.
Addex, a leading company pioneering allosteric modulation-based drug discovery and development, announced today top-line data from a successful Part B of the first-in-patient Phase 2a clinical study of ADX71149 in schizophrenia, that was conducted by Janssen Research & Development, LLC, on behalf of its affiliate Janssen Pharmaceuticals Inc.
announced today the co-publication, in conjunction with the Stevens Lab at The Scripps Research Institute, of key results relating to its expertise in the determination of high resolution G-protein coupled receptor (GPCR) crystal structures to enable rational drug discovery and design, including for allosteric modulators of GPCR receptors.