allostery

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allostery

[′a·lō‚stir·ē]
(biochemistry)
The property of an enzyme able to shift reversibly between an active and an inactive configuration.
References in periodicals archive ?
The researchers' experiments explored in detail how the region of Abl called the allosteric regulatory module interacted with the kinase domain to control it.
The allosteric effect of p,p '-DDT on the activation of FSHR by 16a strongly suggests that both molecules can bind to FSHR.
A loss of allosteric regulation on the CBS enzyme activity by AdoMet was found to increase the homocysteine level [12].
Apart from accounting for cooperative effects, their modified form also accommodated allosteric feedback inhibition, an important feature of many cellular reactions that M-M kinetics does not explain [7].
based Anchor Therapeutics announced the publication of new research that describes the identification and characterization of a pepducin-based allosteric agonist that targets CXCR4, a chemokinc G protein-coupled receptor (GPCR) found on hematopoietic stem cells and other bone marrow-derived cells.
Their topics include a natural history of sensor domains in bacterial signaling systems, sensing ligands by periplasmic sensing histidine kinases with sensory pas domains, bacterial chemoreceptors as membrane-spanning allosteric enzymes, metal-dependent and metal responsive regulatory systems, and thiol-based sensory factors.
Eszopiclone is a non-benzodiazepine type allosteric GABA agonist discovered by Sepracor.
Vivalis know-how and proprietary technology are focused in three main areas: licensing the proprietary ebx(TM) chicken embryonic stem cell lines to the pharma and biotech industry, in particular for vaccine and proteins production; contract manufacturing of pre-clinical and clinical batches of viral vaccines and recombinant proteins; and discovery of new anti-viral allosteric modulators through its proprietary 3D-Screen(TM)[3] platform.
The topics covered in the subsequent chapters include characterization of enzyme activity by the equilibrium and steady-state models; reversible, irreversible, and mechanism-based (alternate and suicide inhibition) enzyme inhibition; effects of pH on enzyme reactions; mechanisms of enzyme reactions; two- and multisubstrate reactions; immobilized, interfacial, and allosteric enzymes; transient phases of enzyme reactions; and enzyme stability.
The oxygen binding affinity of natural human hemoglobin is too high when it is free in the blood stream (not contained within erythrocytes) because of a lack of allosteric control.
This property is allostery, and a protein is allosteric if it can increase or decrease its ability to participate in a reaction.