Ohta, 1994, "T and R States in the Crystals of Bacterial L-lactate Dehydrogenase Reveal the Mechanism of
Allosteric Control", Natural Structure Biology, no.
This subversion of the
allosteric control allows another molecule of ceftaroline to access the active site, which inhibits the function of the enzyme, leading to cell death by MRSA.
Metabolic plasticity of skeletal muscle tissue involves faster changes in enzyme activity via
allosteric control as well as post-translational modifications that increase the control of mitochondrial content and substrate preference (16,19).