allosteric site


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Related to allosteric site: competitive inhibition

allosteric site

[¦a·lə¦ster·ik ′sīt]
(biochemistry)
The inactive (or less active) region of an enzyme molecule.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The compounds with the highest pharmacophore fit scores are screened and docked on the identified allosteric site of NS2B-NS3.
Meanwhile, HM-1 (-7.2 kcal/mol) bound to CYP2C9-10G5 in the allosteric site via Sigma-Pi interaction with Phe100, different from tolbutamide (-6.8 kcal/mol).
Characterization of the brevenal binding site: an allosteric site affecting voltage sensitive sodium channels Site 5 [doctoral thesisj.
Historically, it has been challenging to rationally develop small molecules against allosteric sites because allosteric pockets are difficult to distinguish from other protein sites.