allostery

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allostery

[′a·lō‚stir·ē]
(biochemistry)
The property of an enzyme able to shift reversibly between an active and an inactive configuration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
They first used the term "allosteric" for naming the inhibitory mechanism triggered by the binding of a ligand to a site in an enzyme distinct from the binding site for the substrates; however, the concept of allosterism was substantially modified in a later paper (Monod, Wyman and Changeux 1965); the application of the new version of allosterism presented in 1965 has grown continuously and today applies to a whole variety of protein behaviors not involving enzymes, such as trans-membrane receptors, membrane channels and transporters.
(2005) Allosterism at muscarinic receptors: ligands and mechanisms.
Conventional peptide therapeutics used previously known to acts as ligands to manipulate function of target protein by its specific extracellular binding, and now they also acts as inhibitory properties for intracellular protein-protein interaction through allosterism [26].