--, 2012, "Allostery
and the Monod-Wyman-Changeux Model After 50 Years", Annual Review of Biophysic, no.
Sousa et al., "The emergence of protein complexes: quaternary structure, dynamics and allostery
," Biochemical Society Transactions, vol.
in a monomeric protein: the case of human serum heme-albumin.
"The greatest potential for impact is in drug discovery and understanding biophysical processes--fundamental questions like allostery
," he says, referring to the subtle process by which biological molecules go about binding to one another.
[33.] Jonczyk, R and Genschel, U, "Molecular adaptation and allostery
in plant pantothenate synthetases", Journal of Biological Chemistry 2006; 281: 37435-37446.
Pinon et al., "Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
," Proceedings of the National Academy of Sciences of the United States of America, vol.
A summary of these data revealed that the allosteric effect is dependent upon the binding effectiveness of reversible inhibitors of protein kinase A, and the principle 'better binding: stronger allostery
' was formulated .
5), which may be due to the observation that (R)-NMSal deleted the allostery
of tyrosine hydroxylase to biopterin and limited catecholamine synthesis (10).
Importantly, an action in one domain could affect other, distally located sites, an event termed allostery
(Kern and Zuiderweg 2004).
This property is allostery
, and a protein is allosteric if it can increase or decrease its ability to participate in a reaction.
Anand et al., "Evolution of allostery
in the cyclic nucleotide binding module," Genome Biology, vol.