allostery


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Related to allostery: angiostenosis, analgia, arthrosteitis

allostery

[′a·lō‚stir·ē]
(biochemistry)
The property of an enzyme able to shift reversibly between an active and an inactive configuration.
References in periodicals archive ?
We are looking at several problems, such as drug discovery, protein analysis, allostery and virus particles," he says.
Jonczyk, R and Genschel, U, "Molecular adaptation and allostery in plant pantothenate synthetases", Journal of Biological Chemistry 2006; 281: 37435-37446.
In the present study allostery was revealed in the protein kinase A catalysed reaction of peptide phosphorylation, and the effect was quantified in terms of the interaction factor [alpha] for seven substrates.
5), which may be due to the observation that (R)-NMSal deleted the allostery of tyrosine hydroxylase to biopterin and limited catecholamine synthesis (10).
Importantly, an action in one domain could affect other, distally located sites, an event termed allostery (Kern and Zuiderweg 2004).
This property is allostery, and a protein is allosteric if it can increase or decrease its ability to participate in a reaction.