alloxan


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Related to alloxan: streptozotocin

alloxan

[ə′läk·sən]
(biochemistry)
C4H2N2O4 Crystalline oxidation product of uric acid; induces diabetes experimentally by selective destruction of pancreatic beta cells. Also known as mesoxyalyurea.
References in periodicals archive ?
Preparations from some herbs can stimulate [beta]-cells regeneration and the consumption of peripheral glucose in diabetic rats induced by streptozotocin and alloxan (Jeon et al., 2013; Ghamarian et al., 2012).
The test animals were white male mice of 20-40 g Wistar strain induced using alloxan at a dose of 200 mg/KgBW until blood glucose levels reached blood glucose levels of diabetes.
Histological analysis showed qualitative and quantitative changes in the typical pancreas architecture after alloxan treatment, particularly in the islets of Langerhans (Figure 2B), with this group displaying necrotic changes in the pancreatic islets.
Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats.
The animals were induced to dyslipidemias by fructose and by hypercholesterolemic ration, as well as diabetes mellitus, by alloxan. Supplementation was performed in all groups by means of an aqueous suspension of P.
Thus, this work is aimed at evaluating the influence of insulin treatment on systemic mycosis caused by Paracoccidioides brasiliensis in a murine model of insulin deficiency (type 1 diabetes mellitus, DM1) induced by alloxan.
Diabetes mellitus was induced by an intravenous (i.v.) injection of 65 mg/kg of alloxan monohydrate dissolved in sterile saline (0.9%, NaCl).
Diabetes was induced in groups A2, B2 and C2 using single intravenous injection of 50mg/kg of alloxan. Animals having fasting blood glucose>250mg/dl were considered diabetic.
The diabetes was induced by subcutaneous injection of Alloxan hydrate (LOBA CHEMIE PVT LTD, Mumbai) in mice, 80mg / kg body weight, after 12 hrs of fasting.
cerevisiae, 4-nitrophenyl-a-D-glucopyranoside (PNPG) as a synthetic substrate, alloxan, and dimethyl sulfoxide (DMSO) were purchased from Sigma (St.