The total number of cells per islet section and the beta and alpha cells
were counted as they differentially stained with chrome alum Hematoxylin-phloxin.
It works by restoring the human beta and alpha cell
populations in the pancreas.
However, the researchers were missing the second half of the pancreatic equation: cells, like alpha cells
, that sense blood sugar and secrete a hormone to offset insulin's effects.
In younger age group, the alcoholism increased the blood glucose level by increasing the appetite as well as by stimulating the alpha cells
Failure to suppress glucagon secretion from the alpha cells
of the pancreas contributes to hyperglycaemia.
In a recently published study in Nature, it is demonstrated that SGLT2 is expressed in glucagon- secreting alpha cells
of the pancreatic islets.14 The investigators further found that expression of SLC5A2 (which encodes SGLT2) was lower and glucagon (GCG) gene expression was higher in islets from type 2 diabetic individuals and in normal islets exposed to chronic hyperglycemia than in islets from non-diabetics.
glucagon-like peptide-1 secretion from L cells and alpha cells
. Nat Med.
GLP-1 is a naturally-occurring peptide hormone that is released within minutes after eating a meal and is known to suppress glucagon secretion from pancreatic alpha cells
and stimulate glucose-dependent insulin secretion by pancreatic beta cells.
This latter finding is likely a consequence of GLP-1--based therapies' suppression of the release of glucagon by alpha cells
, since decreasing the availability or action of the hormone glucagon has been shown in a variety of prior studies to induce a proliferation of pancreatic alpha cells
The two main types of pancreatic cells are alpha cells
and beta cells.
in the pancreas can spontaneously transform into insulin-producing beta cells, researchers report online April 4 in Nature.