lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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.

Lipoic Acid

 

6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
(biochemistry)
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid.
Extensive research and clinical experience have indicated that alpha-lipoic acid is safe, well tolerated, and effective in providing symptomatic relief of diabetic neuropathy.
Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.
Intravenous racemic alpha-lipoic acid appears to be a useful ancillary treatment for symptoms of diabetic polyneuropathy, Dr.
Among the products in the catalogue named "Diabetic Health" are Multivitamin Formula, Eye Care Formula and Neuropathy Formula based on a number of well recognized nutritional supplements, such as Chromium, Vitamin E, Alpha-lipoic Acid, Vanadyl Sulfate, Bilberry Extract, and Coenzyme Q10.
R-ALA: Alpha-lipoic acid has numerous benefits to the diabetic patient.
Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways.
com conducted on alpha-lipoic acid supplements, indicate that two brands contained less of this natural antioxidant than promised on labels.
Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy," Rom J Intern Med, July-September 1999.
Studies show that the antioxidant alpha-lipoic acid works to normalize and lower blood sugar levels.