24 different isoforms are generated from alternative RNA splicing
and RNA editing, it depends on the target site where WT1 is binding.
"Although vaccines and some antiviral drugs are available, it is crucial to understand influenza virus-host interactions at a molecular level in order to identify host vulnerabilities targeted by flu viruses, which could lead to developing new therapeutic options," said Lynch, whose lab focuses on the specific mechanisms and patterns of alternative RNA splicing
and how it relates to human disease,
The phenomenon of alternative RNA splicing
- where a single gene can encode multiple proteins - was discovered over 30 years ago in viruses.
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing
. Science 1987; 236:799-807.
ExonHit Therapeutics is the world's leader in the analysis of alternative RNA splicing
, a process which when deregulated plays a key role in the onset of various diseases.
Computational analysis and experimental validation of tumor-associated alternative RNA splicing
in human cancer.
ExonHit Therapeutics is a world-leading company in developing novel pharmaceuticals and diagnostics from its unique understanding of alternative RNA splicing
, the process by which a single gene can lead to several proteins.
There is a second way to generate diversity, called alternative RNA splicing. The Harvard group and others have found evidence of it in muscle proteins, and researchers at other laboratories have seen it in immune system proteins, some nervous system proteins and blood proteins.
Nadal-Ginard found the alternative RNA splicing in a muscle protein serendipitously, he says.