amantadine


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amantadine

[ə′man·tə‚dēn]
(pharmacology)
C10H17N A symmetrical amine used as a viral chemoprophylactic because it selectively inhibits certain myxoviruses; also of value in the treatment of parkinsonism.
References in periodicals archive ?
On the basis of cycling probe real-time PCR assay, these viruses had an S31N mutation in M2, which confers resistance to amantadine. All subtype H3N2 viruses analyzed in this study remain sensitive to oseltamivir carboxylate (Table).
A double-blind, placebo-controlled, crossover study demonstrated a trend toward treatment benefit with a 6-week course of amantadine in the acute phase of severe TBI using outcome measures of Mini-Mental State Examination (MMSE), Glasgow Outcome Scale (GOS), and Disability Rating Scale (DRS) [26].
PCPs were asked to identify all antiviral agents they prescribed; 87.0% prescribed oseltamivir, 17.8% amantadine, 8.7% rimantadine, and 5.3% zanamivir (Table 1).
Amantadine inhibits an early step in the viral replication process, probably viral uncoating, and also has an effect on one of the final steps of viral assembly in some strains.
Amantadine, used to treat symptoms of influenza A virus, is being offered only in 100-mg capsules.
KEY WORDS: amantadine, dyskine-sias, side-effects, clinical practice
Evidence of widespread resistance of influenza to amantadine and rimantadine has prompted calls for restraint in antiviral use in order to preserve the therapeutic value of these adamantanes as well as newer generation agents.
Amantadine (Symmetrel) has demonstrated a modest benefit on MS fatigue and is much less expensive than modafinil.
The gene sequences of the viruses indicated they were sensitive to the antiviral drugs Tamiflu and amantadine.
If you are older or in poor health, your doctor may prescribe amantadine, oseltamivir, or zanamivir if you have been exposed to the flu virus or if you have flu symptoms.
Until then, four different antiviral drugs (amantadine, rimantadine, oseltamivir, and zanamivir) are approved by the U.S.
The M2 blocker amantadine is widely used and available without a prescription in some countries, including China, note Yi Guan and Honglin then, both of the University of Hong Kong and Shantou University Medical College in China.