Generic pharmaceutical company Lannett Company Inc (NYSE:LCI) reported on Friday the receipt of approval for its Abbreviated New Drug Application (ANDA) for Amantadine Hydrochloride
Capsules USP, 100 mg from the US Food and Drug Administration (FDA).
However, slowly administered intravenous physostigmine in 1 and 2 mg doses in an adult2 at 1- to 2-hour intervals and 0.5 mg doses in a child3 at 5- to 10-minute intervals up to a maximum of 2 mg/hour have been reported to be effective in the control of central nervous system toxicity caused by Amantadine hydrochloride
. For acute overdosing, general supportive measures should be employed along with immediate gastric lavage or induction of emesis.
Efficacy and safety of low dosage amantadine hydrochloride
as prophylaxis for influenza A.
Experiments on cells taken from fish and other animals are three times as effective as amantadine hydrochloride
, the widely available basis of many modern flu remedies.
The 4 approved therapeutic medications (amantadine hydrochloride
, rimantadine hydrochloride, zanamivir, and oseltamivir) must be started within 30 to 48 hours of initial symptoms for any appreciable benefit to the patient, yet only a small fraction of patients present to their primary care providers within this time frame.
Morton Grove, another manufacturer and marketer of a broad line of generic drugs, was granted its first ANDA approval of this year for amantadine hydrochloride
syrup USP 50 mg./5 ml.
Antiviral agents available for the prophylaxis or treatment of influenza type A infection are amantadine hydrochloride
and rimantadine hydrochloride.
There is one prescription antiviral medicine, amantadine hydrochloride
, that can shorten the course of one serious form of influenza if taken shortly after its onset.
The United States Food and Drug Administration has received a New Drug Application (NDA) from United States-based Adamas Pharmaceuticals for its ADS-5102 (amantadine hydrochloride
) extended-release capsules, the company's lead product candidate, it was reported on Friday.