amatoxin

[¦am·ə¦täk·sən]

(biochemistry)

Any of a group of toxic peptides that selectively inhibit ribonucleic acid polymerase in mammalian cells; produced by the mushroom Amanita phalloides.

References in periodicals archive ?

In 2006, an outbreak occurred among two Hmong ([dagger]) families in Minnesota who consumed Amanita bisporigera; this mushroom produces amatoxin, which is associated with gastrointestinal distress, liver failure, and high mortality.

Acute Intoxications from Consumption of Amanita muscaria Mushrooms--Minnesota, 2018

Treatment of amatoxin poisoning: 20-year retrospective analysis.

Promote LIVER Detoxification

Most of the cases reported from upper Assam are amatoxin poisoning.

Mushroom poisoning induced acute liver failure with deranged coagulation profile

Phalloides contains amatoxin, which can cause acute liver failure and death.

A narrative review of acute adult poisoning in Iran

tigrinus slightly more toxic than Cortinarius speciosissimus and Cortinarius orellanus with L[D.sub.50] values of 2.0 g/kg and 3.2 g/kg, respectively [8] but less toxic compared to the 10 mg lethal dose of Amanita phalloides amatoxin reported by Patowary [9].

Biological activity of the Tiger mushroom (Lentinus tigrinus with notes on its assessment for therapeutic consideration

phalloides produces 2 types of toxins: phallotoxins and amatoxin. The phallotoxins are not absorbed from the gut and are believed to be responsible for the nausea, vomiting and diarrhea.

Recollections: Lily Robinson and up in arms

However, a postmortem found Brian, a student at Galway/Mayo Institute of Technology, died of liver failure due a toxic reaction to amatoxin which is found in another type of fungi.

TRAGIC MUSHROOMS; Disabled man was poisoned by fungi

The hepatotoxic agents like pyrrolizidine alkaloids and plants producing these, aflatoxins and amatoxin of Amantia phalloides have been associated with acute onset hepatopathy (30).

Recurrent annual outbreaks of a hepato-myo-encephalopathy syndrome in children in western Uttar Pradesh, India

Prompt identification of mushroom-related toxic symptoms in the ED and early, aggressive IV volume replacement are critical first steps in diminishing the significant morbidity and mortality associated with amatoxin ingestion.

Amanitaphalloides Mushroom Poisonings--Northern California, December 2016

Unfortunately, these mushrooms have no unique smell or taste characteristics, and cooking does not destroy the two types of cyclic oligopeptide toxins, the amatoxin and the phallotoxins.

Management of maternal Amanita phalloides poisoning during the first trimester of pregnancy: a case report and review of the literature

Creative Biolabs provides transcription toxins such as amatoxins (targeting RNA polymerase II) and thailanstatin A (targeting spliceosome) as ADC payloads.

Creative Biolabs Provides Customized Payload Services for Antibody-drug Conjugate

The principal toxins (amatoxins) are taken up by hepatocytes and interfere with messenger RNA synthesis, suppressing protein synthesis and resulting in severe acute hepatitis and possible liver failure.