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Related to amelanotic melanoma: Nodular melanoma


see skin cancerskin cancer,
malignant tumor of the skin. The most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. Rarer forms include mycosis fungoides (a type of lymphoma) and Kaposi's sarcoma.
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melanoblastoma; a malignant tumor that consists of melanin-producing cells.

Factors conducive to the development of melanomas include injury and hormonal stimulation, especially during puberty. Melanomas generally occur on the skin; less often, they appear on the retina, pia mater, nasopharynx, larynx, esophagus, and mucosa of the intestine and other organs. Melanomas usually develop at the site of pigmented or depigmented birthmarks, but they may also appear elsewhere. The process starts with a barely perceptible, painless tumor on the skin, sometimes resembling a wart, which gradually becomes dark brown or black. Occasionally, it ulcerates and bleeds. In case of injury, the tumor may enlarge quickly and become tuberous, dense at the base, and stiffer. The regional lymph nodes enlarge. The initial signs that a melanoma is developing at the site of a birthmark are the birthmark’s enlargement, an intensification or reduction in its pigmentation, and the appearance of a red rim around it. Treatment involves prompt surgical intervention, based on early diagnosis, and the use of radiotherapy and drugs to retard the growth and reproduction of the cells.



A malignant tumor composed of anaplastic melanocytes.
A benign or malignant tumor composed of melanocytes.


Pathol a malignant tumour composed of melanocytes, occurring esp in the skin, often as a result of excessive exposure to sunlight
References in periodicals archive ?
Amelanotic melanoma is considered as a great mimic, it can appear as a Bowen neoplasm, an actinic keratosis, lupus erythematosus (as reported by Sbano and Nami15).
Amelanotic melanomas comprise up to 8% of cutaneous melanomas.
Some properties of Bomirski Ab amelanotic melanoma cells, which underwent spontaneous melanization in primary cell culture: growth kinetics, cell morphology, melanin content and tumorigenicity.
Tyrosinase, melan A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections.
Amelanotic melanomas of the nail bed may resemble chronic paronychia or other benign nail conditions, she said.
Dysplastic nevus syndrome with multiple primary amelanotic melanomas in oculocutaneous albinism.
Pigment may be present within the tumor cells or picked up by macrophages in the stroma, although amelanotic melanomas are seen.
These three amelanotic melanomas were clinically suggestive of Bowen's disease, but careful clinical review identified small areas of pigmentation within the erythematous plaques, noted Dr.