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N [up arrow] Ca xP N LN 25-OHD LN [down arrow] 1,25-OHD N N NcAMP N [up arrow] IPTH N [up arrow] Urine: Calcium N LN Phosphate N N Aminoaciduria N O+ Clinical Risk factor Hypocalcaemic * [2.
Ifosfamide administration may produce a Fanconi tubulopathy, characterized by aminoaciduria, hypo-phosphaturia, glucosuria, and inability to acidify the urine.
Histologic changes are paralleled by glucosuria, aminoaciduria, proteinuria, polyuria, and increased excretion of enzymes such as alkaline phosphatase and lactate dehydrogenase (5,10,12,17,20,21) as indicators of altered function of proximal tubules and cell damage, respectively.
The validity of random urine samples for the diagnosis of aminoaciduria has already been established using ion-exchange chromatography methods, although it is commonly accepted that there is a higher variation of amino acid concentrations in untimed samplings (15) and in 12-h urine collections (17) compared with 24-h collections.
Proximal tubular injury is associated with glucosuria, aminoaciduria, lactic aciduria, and 3-D-hydroxybutyric aciduria, along with reduced excretion of citric acid cycle intermediates, such as citrate and succinate (indicative of impaired oxidative metabolism), whereas medullary damage leads to the early appearance of dimethylamine-N-oxide and dimethylamine, followed by increased excretion of acetate and succinate.