In the brain, Firibastat causes the inhibition of aminopeptidase
A (APA) which is a key enzyme in the RAS.
CELTN active site conserved amino acids are same as that of FrvX aminopeptidase
siRNAs targeting the human Filamin B (Filamin B siRNA: sc-60641; Santa Cruz, CA, USA) the Aminopeptidase
N (CD13 siRNA: sc-29960; Santa Cruz), and a scrambled (siRNA-A control: sc-37007; Santa Cruz) mRNAs, were used to transfected BM-MSC cultures by means of Lipofectamine 2000 (Invitrogen, CA, USA) according to the manufacturer's protocol.
BF = bright field, 2D = grown on plastic, 2.5D = grown on transwell inserts, 3D = grown in matrigel sandwich, GGT1 = [gamma]-glutamyltransferase 1, LAP3 = leucine aminopeptidase
3, ALPL = alkaline phosphatase.
Ibrahim, "Studies on acceleration of ras cheese ripening by aminopeptidase
enzyme from buffaloes' pancreas II- utilization of buffaloes' pancreas aminopeptidase
in acceleration of ras cheese ripening," New York Science Journal, vol.
(i) Tagging single-nucleotide polymorphisms (tSNPs) of the endoplasmic reticulum aminopeptidase
(ERAP) 1 and 2 is associated with baseline systolic and diastolic blood pressure (BP).
(LNPEP) is a catalyst in the final step of conversion of angiotensinogen to angiotensin IV.
In lepidopteran larvae, aminopeptidase
N (APN) is one of at least 4 Cry1A protein-binding toxins (Bravo et al.
activity as a rapid diagnostic test to confirm bacterial vaginosis.
Leuconostoc species are incapable of producing leucine aminopeptidase
and pyrrolidonyl arylamidase.
LNPEP, the gene which encodes the [AT.sub.4] receptor, but which may have a more important cellular function as insulin-regulated aminopeptidase
, was also expressed at a low level and its expression did not differ between normal lung tissue and lung tumor tissue.
The maturation of propeptides into functional peptides is performed during the vesicular transport within large dense-core vesicles (LDCVs) and requires the joint action of several endopeptidases (cathepsin L, aminopeptidase
B and E, and prohormone convertase 2) [21-23].